The Johns Hopkins All Children’s Cancer & Blood Disorders Institute seeks to transform childhood cancer care for families throughout Florida and beyond.

We are committed to making it easier for families to find and participate in innovative clinical trials, and to accelerating discoveries from basic science to care at the bedside. Some highlights of our program:

• Johns Hopkins All Children’s Hospital has invested millions in collecting and analyzing data from patients, while removing information that identifies individual patients.
• We collaborate with many of the world’s leading hospitals and technology companies to develop data analysis and machine learning techniques, seeking to discover trends that allow medical intervention before a problem becomes severe.
• Our Institute for Fundamental Biomedical Research conducts basic biomedical research that seeks to understand how the pediatric body works, and the Institute for Clinical and Translational Research applies such discoveries to medical therapies and designs trials to assess their effectiveness.

Clinical Trials

The Cancer & Blood Disorders Institute has more than 100 active clinical trials related to cancer and hematology. These clinical trials offer treatment for many types of cancers, including leukemia, lymphoma, solid tumors, brain tumors and other rare cancers. There are also studies for patients with aplastic anemia, sickle cell disease, hemophilia and other blood disorders. In many cases we anchor multicenter trials with collaborators around the world. We also participate in industry-led trials.

We lead Florida in the number of patients who participate in trials through the Children’s Oncology Group, a worldwide collaboration among children’s hospitals. We are the only site in Florida that has been designated by the Children’s Oncology Group as a Pediatric Early Phase Clinical Trials Network site. Through this network, we are also able to offer novel cancer treatments and therapies to our cancer patients.

We also participate in the Sunshine Project, Beat Childhood Cancer Consortium, Pediatric Transplant and Cellular Therapy Consortium, Pediatric Blood and Marrow Transplant Consortium (PBMTC), North American Pediatric Aplastic Anemia Consortium (NAPAAC), and North American Immuno-Hematology Clinical Education & Research (NICER) Consortium.

Past randomized controlled trials led by Johns Hopkins All Children’s include the groundbreaking Kids-DOTT trial, which found a practice-changing advancement in treatment of children and young adults with blood clots. 

Find a Clinical Trial at Johns Hopkins All Children's

Research Biorepository

Johns Hopkins All Children’s has leading-edge research equipment, including the state’s only accredited pediatric biorepository, which stores biological specimens for use in research. The biorepository has more than a decade of samples related to neuro-oncology research among others. In a new project, the biorepository will be storing sample specimens from patients with many diseases including cancer, sickle cell disease, bone marrow failure diseases, among others.

Data Registries

Data registries in research are used to manage and analyze information on different types of cancer and blood disorders. For instance, patients with a certain type of cancer may be predisposed to develop another condition. Spotting such a trend allows doctors to identify and treat that condition sooner.

The Cancer & Blood Disorders Institute hosts the North American registry for Diamond Blackfan Anemia syndrome, a rare, inherited blood disorder. It is developing a Florida registry for pediatric cancer patients, which will match patients to relevant clinical trials and create a data source for future research.

Florida’s Catalyst for Childhood Cancer Cures

In late 2025, the Cancer & Blood Disorders Institute received a grant from the state of Florida with the goal of accelerating research into childhood cancer. Our proposal focused on five pillars designed to:

• Expand access to and participation in innovative clinical trials
• Develop a statewide interactive database portal to match patients to appropriate trials within the state
• Create a statewide network to move research discoveries into clinical trials faster
• Study how the immune system can be enhanced to fight cancer
• Generate, test and deploy next-generation gene and cellular therapies to combat pediatric cancer

As part of this grant, we also will advance our Cancer Predisposition program to identify children with a genetic predisposition to developing cancer.