The Comprehensive Hemophilia and Bleeding Disorders Treatment Center at Johns Hopkins All Children's provides expert care for children of all ages.
At the Comprehensive Hemophilia and Bleeding Disorders Treatment Center at Johns Hopkins All Children’s Hospital in St. Petersburg, Florida, children and adolescents with hemophilia and other bleeding disorders receive expert, coordinated care. Our team supports infants, children, adolescents, and young adults from diagnosis through early adulthood, promoting confidence, stability, and long-term well-being.
Meet Our Team
Our expert team in the Comprehensive Hemophilia and Bleeding Disorders Treatment Center provides advanced, specialized care to children of all ages. Learn more about our team.
Why Choose Johns Hopkins All Children’s
Care you can trust from infancy through adulthood
Living with a bleeding disorder can be overwhelming—not only medically, but emotionally and practically. Families often face uncertainty about safety, school participation, physical activity, and long-term health. At Johns Hopkins All Children’s, we partner with families to navigate these challenges, providing comprehensive care and services to address all aspects of their child’s life that are impacted by hemophilia or a bleeding disorder.
As a federally designated Hemophilia Treatment Center, our program meets national standards for specialized care proven to reduce bleeding complications and hospitalizations. Our multidisciplinary team works closely together to provide seamless care, clear communication, and timely support—especially when urgent decisions are needed, including 24/7 hematology consultation for emergencies and urgent care needs.
We offer consistent, age‑appropriate care from infancy through early adulthood (ages 21–25), allowing families to avoid disruptions as their child grows. From early diagnosis to daily management, school planning, and the transition to adult care when they become of age, families can rely on a team that understands bleeding disorders—and understands children and young adults. As a federally funded program, we are also recognized by the Centers for Disease Control and Prevention and the National Hemophilia Foundation.
With the right care and ongoing support, children and young adults with bleeding disorders can lead active, healthy lives. Our goal is not only to treat the condition, but to support the whole child and family, every step of the way.
Conditions We Treat
The disorders we treat include:
- Hemophilia A (Factor VIII deficiency) and Hemophilia B (Factor IX deficiency)
- Von Willebrand disease
- Platelet function disorders including Glanzmann thrombasthenia, Bernard-Soulier syndrome, and May-Hegglin anomaly, among others
- Rare bleeding disorders (Factor I, II, V, VII, XI, XIII deficiencies)
- Hereditary Hemorrhagic Telangiectasia (HHT)
- Factor X deficiency
- Ehlers-Danlos syndrome
- Hermansky-Pudlak syndrome
- Other coagulation disorders
Services We Provide
Comprehensive care that supports your child—and your family
Caring for a child with a bleeding disorder often extends beyond medical appointments. Families must navigate treatment routines, school planning, physical activity, and unexpected challenges. Our services are designed to support children and families through every stage of care, with coordination that reduces stress and builds confidence.
Our multidisciplinary team works together to ensure care is seamless, personalized, and responsive—so families know who to call, what to expect, and how to stay supported between visits.
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The Hemophilia and Bleeding Disorders team is led by Dr. Irmel Ayala, national hematology expert in these disorders. She and Dr. Alyson Trillo, along with Dawn Harrison, DNP, will coordinate your child’s care closely with other specialists as needed. Families receive clear guidance, individualized treatment plans, and consistent communication during both routine care and urgent situations.
Physician consultations are available 24/7 to support families during emergencies or unexpected concerns, offering timely medical guidance and reassurance when it matters most. Outpatient clinics in St. Petersburg, Tampa, Lakeland, and Fort Myers make care more accessible and help reduce travel for families.
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Our specialized nursing team serves as a trusted point of contact for families, providing education, care coordination, and hands‑on support between visits. They help families feel confident managing treatment safely at home and in everyday settings.
The nursing team also coordinates infusion services and works closely with other providers and specialists as needed. Between appointments, families can reach out with any questions or care needs that arise.
Support includes assistance with:
- Emergency and travel planning
- Communication with schools and childcare providers
- Training for school nurses
- Outreach to camps, daycare centers, and community programs
School visits are available to support safe classroom participation and care planning.
To contact the nursing team, call the Cancer & Blood Disorders Institute at 727-767-4176 and ask to speak with the bleeding disorders nurse.
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Bleeding disorders can affect joints, muscles, and long-term mobility. Our physical therapists work with patients and families to protect joint health, recognize early signs of bleeding, and support safe movement and activity as children grow.
Each care plan is personalized to help maintain independence, support participation in daily activities, and promote long-term quality of life.
Our physical therapy team evaluates joint and muscle health, helps manage areas affected by bleeding, and guides rehabilitation when needed. They also teach strengthening strategies and joint-friendly exercises, while assessing the need for adaptive equipment, foot support, and orthotics, and coordinating care with other specialists as needed.
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Managing treatment at home is a critical part of care for many families. Our integrated pharmacy program supports safe, timely access to clotting factor products and infusion supplies, helping families stay prepared and confident in daily care.
The pharmacy team provides:
- Cost‑effective clotting factor products
- Infusion supplies and assay management
- 24‑hour access for urgent needs
- Reliable, timely delivery of products
The pharmacy program provides savings to you and your health insurance plan, while also enhancing the services available through the Hemophilia and Bleeding Disorders Treatment Center, and other important clinical care for your family.
Families always retain the right to choose their pharmacy. Our team is available to help families understand their options and make informed decisions that best fit their needs.
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Some families may be interested in participating in research studies or clinical trials that advance the treatment of bleeding disorders. Our team carefully reviews eligibility and discusses potential opportunities with families in a clear, respectful, and thoughtful way.
Participation is always voluntary, and your child’s standard of care is never affected by the decision to participate or not participate in research. Families receive plain language explanations of study goals, expectations, potential benefits, and risks, so they can make informed decisions aligned with their values and comfort level. See our clinical trials.
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For many families, genetic testing helps answer important questions about diagnosis, inheritance, and long-term planning. Our genetics services offer guidance and support families with information that empowers decision‑making and early intervention.
Genetic testing may help with:
- Confirming a diagnosis
- Identifying carriers
- Detecting bleeding disorders early in infants and siblings
- Supporting family planning and education
- Assessing the risk of treatment‑related complications, such as inhibitor development
Families receive guidance and education to help them understand results and next steps in a supportive, thoughtful way.If you would like to learn more about genetic services or request a genetics consultation, please speak with your child’s care team.
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Dental care can be a source of anxiety for families managing a bleeding disorder. Our team helps make routine and specialized dental care as safe and comfortable as possible, with planning that minimizes bleeding risks and stress for both children and caregivers.
We coordinate closely with dental providers to support:
- Preventive dental hygiene and education
- Care planning to reduce bleeding risk during dental procedures
- Referrals to dentists experienced in caring for individuals with bleeding disorders
Families also receive guidance on what to expect before, during, and after dental visits, helping children access essential oral health care with confidence.For more information on dental services, please speak with your child’s care team.
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Bleeding episodes can affect joints, muscles, and long-term movement. Our orthopaedic services focus on early evaluation, prevention, and coordinated management to help children maintain mobility and independence as they grow.
A pediatric orthopaedist works closely with the hematology and physical therapy teams to evaluate joint health, manage complications, and guide treatment decisions. If surgery or advanced intervention is needed, care planning is coordinated to prioritize safety, comfort, and recovery.
Families receive clear explanations, are involved in shared decision‑making, and are offered ongoing support to help manage joint health over time.
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As children grow older and start thinking about their futures, preparing for adult medical care is just as important as thinking about careers and education, financial independence, and other aspects of entering adulthood. Transition to adult care begins early and progresses gradually, with age‑appropriate education and support. Patients are guided in developing skills related to self‑management, healthcare decision‑making, and independence.
With our transition care model, we start the transition process at the age of 12 years by discussing the transition-to-adult-care policy. Between ages 13 and 17, we continue to teach the skills and responsibilities expected of the independent adult. At age 18, we discuss privacy and consent and begin developing a plan for transition to adult care, with the coaching of the parents and the support of the entire care team. By early adulthood (ages 21–25), patients are prepared to transition confidently to adult bleeding disorder specialists—without losing continuity or support.
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Adolescents and young women with bleeding disorders often experience symptoms such as heavy menstrual bleeding that can be difficult to discuss and manage. This specialized clinic offers a supportive environment where patients receive respectful, age‑appropriate care focused on both physical and emotional well‑being.
Care is provided by a multidisciplinary team that includes hematologists, adolescent medicine specialists, nurses, and a social worker with expertise in bleeding disorders. Together, the team addresses diagnosis, symptom management, education, and long‑term health planning.
Learn more about the Young Women's Heavy Periods and Bleeding Disorders Clinic
What to Expect
Caring for a child with a bleeding disorder can be overwhelming. Families often worry about safety, school, activities, emergencies, and what the future may hold. At Johns Hopkins All Children’s, you don’t have to navigate these concerns alone.
Our team provides coordinated, family centered care from infancy through early adulthood (ages 21–25). We work closely with parents and caregivers to create comprehensive care plans, prepare for emergencies, and support your child’s growth and independence over time.
You can expect:
- Clear guidance and communication
- Coordinated care across specialties
- Support during emergencies and transitions
- Care that grows with your child
For our patients, living with a bleeding disorder can affect school, sports, social life, and planning for adulthood. As your child gets older, their health care needs—and their role in managing them—change.
At Johns Hopkins All Children’s, we help teens and young adults build confidence in managing their health. Our team supports our patients in understanding their condition, learning to advocate for themselves, and preparing for the transition to adult care—at a pace that feels right.
Our team provides:
- Care that respects our patients’ voices and choices
- Age‑appropriate education and support
- Help preparing for adult health care
- A team that treats all patients with respect
Information for Referring Providers
As a federally designated Hemophilia Treatment Center, the program meets national standards for specialized care and delivers outcomes associated with fewer bleeding complications, improved coordination, and reduced hospitalizations. Our multidisciplinary team collaborates closely with referring providers to ensure seamless communication, timely access, and continuity of care.
Referring clinicians receive support with:
- Prompt access to pediatric hematology consultations
- Coordinated multidisciplinary management
- Guidance during acute bleeding episodes and peri‑procedural planning
- Clear transition planning for adolescents and young adults
To refer a patient to the Hemophilia and Bleeding Disorders Treatment Center, please fax referrals to 727-767-4379. Please include clinic notes and relevant lab results with the referral.
Resources for Patients and Families
The links provided below are for informational purposes and solely for the user's convenience.
Emergency Assistance
Financial Assistance
Advocacy, Legal Assistance and Education
Our Clinic Locations
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Outpatient Care Center
Johns Hopkins All Children's Hospital 601 5th Street South
St. Petersburg, FL 33701
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Living with a chronic condition affects the whole family. Our social workers provide counseling, emotional support, and practical assistance to help families manage the non‑medical challenges of care.
Support includes guidance with:
We partner with parents on age-appropriate ways to help their children learn and develop health management skills. We’re here to help navigate all aspects of your children’s care.
We offer patients and families emotional support, provide individual and family counseling, and connect them with appropriate community resources. In addition, we coordinate with care teams and community service providers to help meet the family’s needs.
If you would like to speak with a social worker, please speak with your child's care team and they will connect you with our social worker.