Pursuing evidence-based treatments and cures for children
Research is at the heart of all we do at Johns Hopkins All Children’s Hospital. By providing pediatric patients with access to innovative research opportunities, we help advance the diagnosis, treatment, and prevention of pediatric onset diseases and their adverse outcomes.
The Johns Hopkins All Children’s Institute for Clinical and Translational Research, under the leadership of Director Neil Goldenberg, M.D., Ph.D., engages investigators who share a collective passion not only for what the clinical and translational research reveals, but also how one conducts the research (i.e., process is as important as product). This emphasis permeates the education and training activities that the Institute conducts with residents, fellows and faculty/clinicians. The institute also works in parallel with the Institute for Fundamental Biomedical Research, advancing a growing number of interdisciplinary research initiatives and teams that bridge the basic and clinical/translational sciences.
The hospital is a member of the national Institute for Advanced Clinical Trials (I-ACT) for Children, and leaders within the Institute for Clinical and Translational Research serve on several of I-ACT’s leadership committees and task forces. More than 100 full- and part-time faculty of the Johns Hopkins University are based at Johns Hopkins All Children’s and engage in clinical and translational research. Leveraging work and accomplishments made since 2012 at All Children’s, the Johns Hopkins All Children’s Institute for Clinical and Translational Research has launched several research centers and programs, addressing common themes that span the organization’s existing institutes and departments, including:
- Early-phase clinical trials to study innovative pediatric uses of existing medications (the Center for Pediatric Early-Phase Trials)
- Support for multicenter studies (the Clinical Coordinating Center and the Data Coordinating Center)
- Research focused on pediatric health equity, in particular health care access and health outcomes (the Program in Pediatric Health Equity Research)
- Education and training programs for the next generation of clinical/translational scientists focused on child health and disease (the Center for Pediatric Clinical/Translational Research Education, Training and Engagement)
The Johns Hopkins All Children’s institute is integrated within the Baltimore-based Johns Hopkins Institute for Clinical and Translational Research, which receives about $15 million per year from the National Institutes of Health to support investigators as they move discoveries into practice. The institute structures enhance collaboration across Johns Hopkins Medicine campuses. A list of active and/or recently complete clinical trials can be found via clinicaltrials.gov.
Institute for Clinical and Translational Research
Center for Pediatric Clinical Translational Research Training, Education, Engagement and Mentorship
The Center for Pediatric Clinical/Translational Research Training, Education, Engagement and Mentorship serves as an education and training resource to Johns Hopkins All Children’s Hospital principal investigators, sub-investigators and their study team members on best practices for conducting clinical research.
Center for Pediatric Data Science and Analytic Methodology
The focus of the John’s Hopkins All Children’s (JHAC) Center in Pediatric Data Science and Analytic Methodology (PDSAM) is to develop, investigate, disseminate, apply, and educate other researchers and trainees on novel approaches in healthcare data science and new analytic methodologies.
Center for Pediatric Early-Phase Trials
The Center for Pediatric Early-Phase Trials serves as a resource to investigators, including helping to navigate (in partnership with the Center for Pediatric Clinical Research Training, Education and Engagement) investigators through review and approval processes and engaging the expertise of cores and shared resources in order to enhance efficiency and quality of early-phase trial planning and execution.
Clinical Coordinating Center for Pediatric Multicenter Studies
The Clinical Coordinating Center (CCC) for Pediatric Multicenter Studies provides principal investigators (PIs) at Johns Hopkins All Children’s Hospital with the infrastructure to successfully lead and conduct multicenter pediatric studies.
Data Coordinating Center for Pediatric Multicenter Studies
The goal of the Johns Hopkins All Children’s Data Coordinating Center for Pediatric Multicenter Studies is to provide study design, database design, statistical analysis plan development, data management, and analytic plan execution services and expertise for multicenter studies focused on child health and disease.
Center for Pediatric Health Equity Research
The Johns Hopkins All Children’s Center for Pediatric Health Equity Research (CPHER) addresses child health disparities related to maternal/child health, obesity, diabetes, sickle cell disease and adolescent health.
Summer Student Research Training Program
The Johns Hopkins All Children’s Summer Student Research Training Program (SSRTP), Clinical and Translational Research Pathway, develops and mentors passionate students at the undergraduate, medical school and other graduate levels on a career trajectory of a research professional or investigator in clinical and translational research.
Community Research Advisory Board (CRAB)
The Community Research Advisory Board (CRAB) provides community input and guidance on research that takes place in community settings or which might have a substantive impact upon the local/regional community.