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Ongoing Research in Gastroenterology and Hepatology

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  • Aline Charabaty Lab

    The Aline Charabaty Lab performs clinical research on Inflammatory Bowel Disorder.

    Research Areas: Inflammatory Bowel Disorder

    Principal Investigator

    Aline Charabaty Pishvaian, M.D.

    Department

    Medicine

  • Alyssa Parian Lab

    The Alyssa Parian Lab works to identify early markers of dysplasia. We also study inflammatory bowel disease-associated cancers, conduct IBD clinical trials and examine IBD extraintestinal manifestations.

    Research Areas: inflammatory bowel disease, cancer, displaysia

    Principal Investigator

    Alyssa Parian, M.D.

    Department

    Medicine

  • Amy Kim Lab

    The Amy Kim Lab performs basic, translational, and clinical research on liver lesions and hepatocellular carcinoma.

    Research Areas: Liver lesions, hepatocellular carcinoma

    Principal Investigator

    Amy K. Kim, M.D.

    Department

    Medicine

  • Anne Marie Lennon Lab

    The Lennon Lab does clinical and translational research on endoscopic ultrasound, esophageal cancer, gastric cancer, gastroenterology, pancreatic cancer, pancreatic cysts, therapeutic endoscopy, Von Hippel-Lindau (VHL)

    Research Areas: Von Hippel-Lindau (VHL), gastroenterology, pancreatic cancer, Endoscopic Ultrasound, Esophageal Cancer, Pancreatic Cysts, Therapeutic Endoscopy, Gastric Cancer

  • Ashish Nimgoankar Lab

    The Ashish Nimgoankar Lab is interested in translational technology development and image-guided therapies.

    Research Areas: translational technology, imaging

    Principal Investigator

    Ashish Nimgaonkar, M.B.B.S., M.D., M.S.

    Department

    Medicine

  • Brindusa Truta Lab

    The Brindusa Truta Lab studies inflammatory bowel diseases, specifically Crohn’s disease and ulcerative colitis. Recent studies defined factors associated with the development of Crohn's disease after ileal pouch anal anastomosis; determined the value of histology in identifying Lynch syndrome in early-onset of colorectal cancer patients; and compared the phenotype and genotype in adenomatous polyposis patients with and without a family history.

    Research Areas: inflammatory bowel disease, Crohn’s disease, ulcerative colitis

    Principal Investigator

    Brindusa Truta, M.D., M.A.S.

    Department

    Medicine

  • Center for Epithelial Disorders

    The Johns Hopkins Center for Epithelial Disorders focuses on research into the physiology and pathophysiology of epithelial cells (cells that line the cavities and interior surfaces of the body) of the gastrointestinal (GI) tract, liver, pancreas and kidney. Specifically, the center’s research seeks to:

    -Understand the mechanisms regulating the activity of transport proteins (including channels) of epithelial cells
    Characterize the mechanisms by which polarity of epithelial cells are maintained
    -Investigate the mechanisms controlling transcription of epithelial-specific genes
    Understand the pathophysiological basis of GI and renal diseases that involve the preceding three components
    -The center also provides a framework for training fellows in gastroenterology and hepatology to become independent investigators.

    The center is funded primarily through individual investigator-initiated extramural research grant support from the National Institutes of Health (NIH) as well as mult...i-investigator grants including RO1, PO1, UO1 and R24. view more

    Research Areas: gastroenterology, epithelial cells

    Principal Investigator

    Mark Donowitz, M.D.

    Department

    Medicine
    Physiology

  • Chung-Ming Tse

    The Tse Lab does basic and translational research on the function and regulation of sodium/hydrogen exchange-2 isoform, and molecular biology of nucleoside transporters.

    Research Areas: Function and regulation of sodium/hydrogen exchange-2 isoform, molecular biology of nucleoside transporters

    Principal Investigator

    Ming-Tseh Lin, M.D., Ph.D.

    Department

    Medicine

  • Cynthia Sears Laboratory

    Work in the Cynthia Sears Laboratory focuses on the bacterial contributions to the development of human colon cancer and the impact of the microbiome on other cancers and the therapy of cancer. The current work involves mouse and human studies to define how enterotoxigenic Bacteroides fragilis, pks+ Escherichia coli, Fusobacterium nucleatum, biofilms and the colonic microbiota induce chronic colonic inflammation and colon cancer. Prospective human studies of the microbiome and biofilms in screening colonoscopy are in progress as are studies to determine if and how the microbiome impacts the response of individuals with cancer to immunotherapy and other cancer therapies.

    Research Areas: epidemiology, AIDS, microbiome, colon cancer, enterotoxigenic Bacteroides fragilis, chronic colonic inflammation

    Principal Investigator

    Cynthia Sears, M.D.

    Department

    Medicine
    Oncology

  • Doan Dao Lab

    The Doan Dao Lab performs clinical research on Hepatitis B.

    Research Areas: hepatitis B

    Principal Investigator

    Doan Dao, M.D.

    Department

    Medicine

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