Skip Navigation

Jennifer Dianne Foulke-Abel, Ph.D.

Headshot of Jennifer Dianne Foulke-Abel
  • Assistant Professor of Medicine

Research Interests

Intestinal Organoids/enteroids; Intestinal Stem cells; Host-pathogen Interactions; Epithelial Wound Healing ...read more

Background

Dr. Jennifer Foulke-Abel is an Assistant Professor of Medicine in the Division of Gastroenterology & Hepatology at the Johns Hopkins University School of Medicine. Her research focuses on infectious diarrheal diseases and adult stem cell-based models of wound repair.  

Dr. Foulke-Abel received her undergraduate degree and her Ph.D. in Biological Chemistry from Texas A&M University and completed her postdoctoral research training fellowship in Gastroenterology at Johns Hopkins University School of Medicine prior to joining the faculty.

...read more

Titles

  • Assistant Professor of Medicine

Departments / Divisions

Education

Degrees

  • B.A.; Texas A&M University (Texas) (2004)
  • Ph.D.; Texas A&M University (Texas) (2010)

Research & Publications

Research Summary

Dr. Foulke-Abel’s research focuses in part on identifying preventatives and therapies to treat infectious diarrheal diseases such as cholera and E. coli. Her work utilizes intestinal organoids her team has established from adult intestinal stem cells to recapitulate all of the segments of the human gut.

Dr. Foulke-Abel is also engaged in studies to understand and optimize epithelial wound healing using the intestinal organoid model.

Technology Expertise Keywords

Organoids/enteroids; stem cells

Selected Publications

Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M. Human enteroids/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology. J Biol Chem. 2016 Feb 19;291(8):3759–66. doi: 10.1074/jbc.R114.635995. PMID: 26677228.

Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M.  Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood) 2014 Sep;239(9):1124-34. doi: 10.1177/1535370214529398.

In JG, Foulke-Abel J, Clarke E, Kovbasnjuk O. Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium. J Vis Exp. 2019 Apr 9;(146):10.3791/59357. doi: 10.3791/59357.

Foulke-Abel J, Yu H, Sunuwar L, Lin R, Fleckenstein JM, Kaper JB, Donowitz M.  Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection. Gut Microbes. 2020 Nov 9;12(1):1752125. doi: 10.1080/19490976.2020.1752125.

Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. 2016 Mar;150(3):638-649.e8. doi: 10.1053/j.gastro.2015.11.047.

Contact for Research Inquiries

Foulke-Abel Lab
720 Rutland Ave
Ross 929
Baltimore, MD 21205 map

Activities & Honors

Memberships

  • American Gastroenterological Association
  • American Physiological Society
Is this you? Edit Profile
back to top button