Research Summary
Dr. Foulke-Abel’s research focuses in part on identifying preventatives and therapies to treat infectious diarrheal diseases such as cholera and E. coli. Her work utilizes intestinal organoids her team has established from adult intestinal stem cells to recapitulate all of the segments of the human gut.
Dr. Foulke-Abel is also engaged in studies to understand and optimize epithelial wound healing using the intestinal organoid model.
Technology Expertise Keywords
Organoids/enteroids; stem cells
Selected Publications
Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M. Human enteroids/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology. J Biol Chem. 2016 Feb 19;291(8):3759–66. doi: 10.1074/jbc.R114.635995. PMID: 26677228.
Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M. Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood) 2014 Sep;239(9):1124-34. doi: 10.1177/1535370214529398.
In JG, Foulke-Abel J, Clarke E, Kovbasnjuk O. Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium. J Vis Exp. 2019 Apr 9;(146):10.3791/59357. doi: 10.3791/59357.
Foulke-Abel J, Yu H, Sunuwar L, Lin R, Fleckenstein JM, Kaper JB, Donowitz M. Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection. Gut Microbes. 2020 Nov 9;12(1):1752125. doi: 10.1080/19490976.2020.1752125.
Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. 2016 Mar;150(3):638-649.e8. doi: 10.1053/j.gastro.2015.11.047.
