Mouen A Khashab, M.D.

Headshot of Mouen A Khashab
  • Director of Therapeutic Endoscopy
  • Professor of Medicine

Languages: English, Arabic


Achalasia, Bile Duct Disease, Cholangiocarcinoma, Cholangioscopy, Colon Polyps, Endoscopic Resection, Endoscopic Retrograde Cholangiopancreatography, Endoscopic Submucosal Dissection (ESD), Endoscopic Ultrasound, Gastroenterology, Innovative Endoscopy, Pancreatic and Biliary Disease, Pancreatic Cancer, Pancreatic Cysts, Pancreatitis, Peroral Endoscopic Myotomy (POEM), Radiofrequency Ablation (RFA), Sclerosing Cholangitis, Therapeutic Endoscopy, Transoral Incisionless Fundoplications (TIF) more

Research Interests

spasmatic esophageal disorders; endoscopic myotomy; esophageal cancer more

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-933-7495
1800 Orleans St.
Sheikh Zayed Tower, Suite 7125G
Baltimore, MD 21287
Phone: 443-287-1960
The Johns Hopkins Hospital (Main Entrance) - Google Maps


Specializing in therapeutic endoscopy, Dr. Khashab is an expert in advanced and innovative endoscopic techniques, including ERCP, balloon-assisted enteroscopy, endoscopic mucosal resections, and interventional EUS, including the use of EUS to facilitate ERCP. He also has clinical interests in removing large colon polyps. Dr. Khashab’s research interests include natural orifice translumenal endoscopic surgery (NOTES). 

Dr. Khashab is an associate editor of the Fellows Corner section of Gastrointestinal Endoscopy. He has published more than 50 papers and book chapters. more


  • Director of Therapeutic Endoscopy
  • Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; American University of Beirut Faculty of Medicine (2002)


  • Categorical Medicine; Indiana University School of Medicine (2006)


  • Gastroenterology; Indiana University School of Medicine (2009)
  • Gastroenterology; Johns Hopkins University School of Medicine (2011)

Board Certifications

  • American Board of Internal Medicine (Gastroenterology) (2021)

Research & Publications

Selected Publications

View all on PubMed

Kumbhari V, Khashab MA., Peroral endoscopic myotomy. World J Gastrointest Endosc. 2015 May 16;7(5):496-509. doi: 10.4253/wjge.v7.i5.496.

Khashab MA, Messallam AA, Onimaru M, Teitelbaum EN, Ujiki MB, Gitelis ME, Modayil RJ, Hungness ES, Stavropoulos SN, El Zein MH, Shiwaku H, Kunda R, Repici A, Minami H, Chiu PW, Ponsky J, Kumbhari V, Saxena P, Maydeo AP, Inoue H., International multicenter experience with peroral endoscopic myotomy for the treatment of spastic esophageal disorders refractory to medical therapy (with video). Gastrointest Endosc. 2015 May;81(5):1170-7. doi: 10.1016/j.gie.2014.10.011. Epub 2015 Jan 26.

Khashab MA, El Zein M, Kumbhari V, Besharati S, Ngamruengphong S, Messallam A, Abdelgalil A, Saxena P, Tieu AH, Raja S, Stein E, Dhalla S, Garcia P, Singh VK, Pasricha PJ, Kalloo AN, Clarke JO., Comprehensive analysis of efficacy and safety of peroral endoscopic myotomy performed by a gastroenterologist in the endoscopy unit: a single-center experience. Gastrointest Endosc. 2016 Jan;83(1):117-25. doi: 10.1016/j.gie.2015.06.013. Epub 2015 Jul 26.

Kumbhari V, Besharati S, Abdelgelil A, Tieu AH, Saxena P, El-Zein MH, Ngamruengphong S, Aguila G, Kalloo AN, Khashab MA., Intraprocedural fluoroscopy to determine the extent of the cardiomyotomy during per-oral endoscopic myotomy (with video). Gastrointest Endosc. 2015;81(6):1451-6. doi: 10.1016/j.gie.2015.01.052. Epub 2015 Apr 14.

Khashab MA, Kumbhari V, Azola A, Zein ME, Messallam AA, Abdelgelil A, Besharati S, Kalloo AN, Saxena P., Intraoperative determination of the adequacy of myotomy length during peroral endoscopic myotomy (POEM): the double-endoscope transillumination for extent confirmation technique (DETECT)., Endoscopy. 2015 Oct;47(10):925-8. doi: 10.1055/s-0034-1391900. Epub 2015 Apr 7.

Videos & Media

Recent News Articles and Media Coverage

Johns Hopkins Among First to offer Flexible Robotic Endoscopy, Inside Tract (Winter, 2019)

Myotomy Offers Relief for Some Gastroparesis Patients, Inside Tract (Spring, 2017)

Bringing Bile, Pancreatic Ducts into Better Focus, Inside Tract (Summer, 2016) 

Surgery-Saving Endoscopic Stitching For Weight Loss, Inside Tract (Fall, 2015)

POEM to Ease Esophageal Passage, Inside Tract (Spring, 2015)

For Health Care Providers:

Johns Hopkins Clinical Connection: A Novel Approach for the Treatment of Zenker's Diverticulum:Z-POEM

Johns Hopkins Clinical Connection Endoscopic GastroJejunostomy: A Novel Procedure for Treatment of Gastric Outlet Obstruction (Video)


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