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Viral Hepatitis Center

Clinical research programs in viral hepatitis include:

FieldLeaderResearch Focus

HCV care models


Elimination of hepatitis C through development of models to improve hepatitis C testing, linkage to care and treatment for people who inject drugs, HIV infected and other marginalized populations 

HIV/HCV coinfection


HIV and HCV prevention and linkage to care/treatment interventions particularly as they intersect with the social determinants of health; Directs Generation Tomorrow and HIV/HCV training programs for students and community members for the Center for AIDS Research (CFAR)

Treatment of viral hepatitis infection


Clinical trials and studies of novel antiviral drugs and implementation strategies for the treatment of individuals with hepatitis B or C virus infection and the elimination/control of these infections in impacted patient populations. 
Search for Hepatitis C Trials

The Center also has extensive basic research programs related to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, including:

FieldLeaderResearch Focus

Hepatitis C virus Humoral immune response


Study of immune responses against hepatitis C virus, particularly neutralizing antibody responses, with the goal of guiding vaccine development against the virus

Immunology (Innate) Hepatic Inflammation


Microbial translocation and Kupffer cells in HIV-HCV coinfection
In situ liver studies of HIV-HCV pathogenesis

Innate immunity to viruses HIV/HCV Vaccine development


Study of innate immune system responses against chronic viral infections including hepatitis C virus, hepatitis B, and HIV

Immunology (Cellular) Vaccine development


Cellular immune responses to HCV and HBV during acute and chronic infection
Mechanisms of T cell regulation and immune failure during the transition from acute to chronic viral infection

HBV immunology HIV/HCV coinfection Diagnostics


Viral molecular nanodiagnostics
Neutralizing antibody responses during acute HBV infection
Immune responses  to HCV following HAART during HIV/HCV coinfection

Virology / Evolution


Evolution and immune evasion of the HCV genome during acute and chronic infection

Human Genetics
HIV/HBV Coinfection


Human genetic variation affecting the outcomes of HBV and HCV infections 
Treatment and virology of HBV and HIV coinfection
HBV immunology and virology with the goal of HBV cure



Pathogenesis of chonic viral liver disease including host genetics 
Role of HIV modifying forms and expression of liver disease Virome