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School of Medicine
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Viral Hepatitis Center
Clinical research programs in viral hepatitis include:
HCV care models
Elimination of hepatitis C through development of models to improve hepatitis C testing, linkage to care and treatment for people who inject drugs, HIV infected and other marginalized populations
HIV and HCV prevention and linkage to care/treatment interventions particularly as they intersect with the social determinants of health; Directs Generation Tomorrow and HIV/HCV training programs for students and community members for the Center for AIDS Research (CFAR)
Treatment of viral hepatitis infection
Clinical trials and studies of novel antiviral drugs and implementation strategies for the treatment of individuals with hepatitis B or C virus infection and the elimination/control of these infections in impacted patient populations.
The Center also has extensive basic research programs related to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, including:
Hepatitis C virus Humoral immune response
Study of immune responses against hepatitis C virus, particularly neutralizing antibody responses, with the goal of guiding vaccine development against the virus
Immunology (Innate) Hepatic Inflammation
Microbial translocation and Kupffer cells in HIV-HCV coinfection
Innate immunity to viruses HIV/HCV Vaccine development
Study of innate immune system responses against chronic viral infections including hepatitis C virus, hepatitis B, and HIV
Immunology (Cellular) Vaccine development
Cellular immune responses to HCV and HBV during acute and chronic infection
HBV immunology HIV/HCV coinfection Diagnostics
Viral molecular nanodiagnostics
Virology / Evolution
Evolution and immune evasion of the HCV genome during acute and chronic infection
Human genetic variation affecting the outcomes of HBV and HCV infections
Pathogenesis of chonic viral liver disease including host genetics