Research Summary
Our research projects focus on sensory afferent neurobiology and nerve-immune interactions in the GI tract. Specifically, we are interested in studying the cellular and molecular mechanisms underlying vagal afferent nerve activation and mast cell activation-induced sensitization of vagal nociceptive afferents in the esophagus.
For research inquiries please contact Dr. Yu via email at syyu@jhmi.edu.
Technology Expertise Keywords
Esophageal Physiology, Vagal Afferent Neurobiology, and Mast Cell Biology
Selected Publications
View all on PubMed
Liu Z, Hu Y, Yu X, Xi J, Fan X, Tse CM, Myers AC, Pasricha PJ, Li X, Yu S. Allergen challenge sensitizes TRPA1 in vagal sensory neurons and afferent C-fiber subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G482-8.
Yu X, Yu M, Liu Y, Yu S. TRP channel functions in the gastrointestinal tract. Semin Immunopathol. 2016 May;38(3):385-96.
Huang Y, Patil MJ, Yu M, Liptak P, Undem BJ, Dong X, Wang G, Yu S. Effects of ginger constituent 6-shogaol on gastroesophageal vagal afferent C-fibers. Neurogastroenterol Motil. 2019 Jun;31(6):e13585
Yu M, Chang C, Undem BJ, Yu S. Capsaicin-Sensitive Vagal Afferent Nerve-Mediated Interoceptive Signals in the Esophagus. Molecules 2021 Jun 28;26(13):3929. PMCID: PMC8271978.
Yu X, Hu Y, Yu M, Undem BJ, Yu S. Deoxycholic acid activates and sensitizes vagal nociceptive afferent C-fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2021 Aug 1;321(2):G149-G156
