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Background

Dr. Shaoyong Yu is an Associate Professor of Medicine in the Division of Gastroenterology and Hepatology, Department of Medicine. His studies focus on neurogastroenterology and motility disorders.

Dr. Yu received medical and master’s degrees from Yichang and Tongji Medical Colleges, and a master of public health (MPH) degree from the Johns Hopkins Bloomberg School of Public Health.  Before joining the Johns Hopkins faculty, he completed three-year research fellowship training at Johns Hopkins University School of Medicine, focusing on gastrointeastinal motility disorders, plus an additional two-year postdoctoral training in sensory neurobiology at JHU.

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Education

Degrees

  • M.D.; Yichang Medical College (China) (1986)

Additional Training

  • Johns Hopkins University School of Medicine, Division of Gastroenterology and Hepatology, Baltimore, MD, Clinical Research Fellow
  • Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, MD, Post-doctoral Fellow

Research & Publications

Research Summary

Our research projects focus on sensory afferent neurobiology and nerve-immune interactions in the GI tract. Specifically, we are interested in studying the cellular and molecular mechanisms underlying vagal afferent nerve activation and mast cell activation-induced sensitization of vagal nociceptive afferents in the esophagus.

For research inquiries please contact Dr. Yu via email at syyu@jhmi.edu.

Technology Expertise Keywords

Esophageal Physiology, Vagal Afferent Neurobiology, and Mast Cell Biology

Selected Publications

Liu Z, Hu Y, Yu X, Xi J, Fan X, Tse CM, Myers AC, Pasricha PJ, Li X, Yu S. Allergen challenge sensitizes TRPA1 in vagal sensory neurons and afferent C-fiber subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G482-8.

Yu X, Yu M, Liu Y, Yu S. TRP channel functions in the gastrointestinal tract. Semin Immunopathol. 2016 May;38(3):385-96.

Huang Y, Patil MJ, Yu M, Liptak P, Undem BJ, Dong X, Wang G, Yu S. Effects of ginger constituent 6-shogaol on gastroesophageal vagal afferent C-fibers. Neurogastroenterol Motil. 2019 Jun;31(6):e13585

Yu M, Chang C, Undem BJ, Yu S. Capsaicin-Sensitive Vagal Afferent Nerve-Mediated Interoceptive Signals in the Esophagus. Molecules 2021 Jun 28;26(13):3929. PMCID: PMC8271978.

Yu X, Hu Y, Yu M, Undem BJ, Yu S. Deoxycholic acid activates and sensitizes vagal nociceptive afferent C-fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2021 Aug 1;321(2):G149-G156

Contact for Research Inquiries

Email me Phone: 410-502-2455
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