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Shaoyong Yu, M.D.

Headshot of Shaoyong Yu
  • Associate Professor of Medicine


Dr. Shaoyong Yu is an Associate Professor of Medicine in the Division of Gastroenterology and Hepatology, Department of Medicine. His studies focus on neurogastroenterology and motility disorders.

Dr. Yu received medical and master’s degrees from Yichang and Tongji Medical Colleges, and a master of public health (MPH) degree from the Johns Hopkins Bloomberg School of Public Health.  Before joining the Johns Hopkins faculty, he completed three-year research fellowship training at Johns Hopkins University School of Medicine, focusing on gastrointeastinal motility disorders, plus an additional two-year postdoctoral training in sensory neurobiology at JHU. more



  • M.D.; Yichang Medical College (China) (1986)

Additional Training

  • Johns Hopkins University School of Medicine, Division of Gastroenterology and Hepatology, Baltimore, MD, Clinical Research Fellow
  • Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, MD, Post-doctoral Fellow

Research & Publications

Research Summary

Dr. Yu's research has been focused on sensory afferent neurobiology and never-immune interactions in the GI tract. Specifically, he is interested in studying the cellular and molecular mechanisms underlying vagal afferent activation and mast cell activation-induced sensitization of visceral afferents in the GI tract.

For research inquiries please contact Dr. Yu via email at

Technology Expertise Keywords

Esophageal Physiology, Vagal Afferent Neurobiology, and Mast Cell Biology

Selected Publications

Liu Z, Hu Y, Yu X, Xi J, Fan X, Tse CM, Myers AC, Pasricha PJ, Li X, Yu S. Allergen challenge sensitizes TRPA1 in vagal sensory neurons and afferent C-fiber subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G482-8.

Yu X, Yu M, Liu Y, Yu S. TRP channel functions in the gastrointestinal tract. Semin Immunopathol. 2016 May;38(3):385-96.

Yu X, Patil MJ, Yu M, Liu Y, Wang J, Undem BJ, Yu S. Sphingosine-1-phosphate selectively activates vagal afferent C-fiber subtype in guinea pig esophagus. Neurogastroenterol Motil. 2018 Sep;30(9):e13359.

Hu Y, Yu X, Yu S. QX-314 inhibits acid-induced activation of esophageal nociceptive C fiber neurons. Neurogastroenterol Motil. 2019 Apr;31(4):e13543.

Huang Y, Patil MJ, Yu M, Liptak P, Undem BJ, Dong X, Wang G, Yu S. Effects of ginger constituent 6-shogaol on gastroesophageal vagal afferent C-fibers. Neurogastroenterol Motil. 2019 Apr 4:e13585.

Contact for Research Inquiries

Phone: 410-502-2455
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