Our research projects focus on sensory afferent neurobiology and nerve-immune interactions in the GI tract. Specifically, we are interested in studying the cellular and molecular mechanisms underlying vagal afferent nerve activation and mast cell activation-induced sensitization of vagal nociceptive afferents in the esophagus.
For research inquiries please contact Dr. Yu via email at [email protected].
Technology Expertise Keywords
Esophageal Physiology, Vagal Afferent Neurobiology, and Mast Cell Biology
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Hu Y, Liu Z, Yu X, Pasricha PJ, Undem BJ, Yu S. Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G149-57
Yu X, Hu Y, Yu S. Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15;307(4):G471-8
Yu X, Yu M, Liu Y, Yu S. TRP channel functions in the gastrointestinal tract. Semin Immunopathol. 2016 May;38(3):385-96
Yu X, Hu Y, Yu M, Undem BJ, Yu S. Deoxycholic acid activates and sensitizes vagal nociceptive afferent C-fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2021 Aug 1;321(2):G149-G156
Patil MJ, Huang Y, Yu M, Dong X, Undem BJ, Yu S. Ginger Constituent 6-Shogaol Attenuates Vincristine-Induced Activation of Mouse Gastroesophageal Vagal Afferent C-Fibers. Molecules. 2022 Nov 2;27(21):7465