Dr. Shaoyong Yu is an Associate Professor of Medicine in the Division of Gastroenterology and Hepatology, Department of Medicine. His studies focus on neurogastroenterology and motility disorders.

Dr. Yu received medical and master’s degrees from Yichang and Tongji Medical Colleges, and a master of public health (MPH) degree from the Johns Hopkins Bloomberg School of Public Health.  Before joining the Johns Hopkins faculty, he completed three-year research fellowship training at Johns Hopkins University School of Medicine, focusing on gastrointestinal motility disorders, plus an additional two-year postdoctoral training in sensory neurobiology at JHU. more


  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • M.D.; Yichang Medical College (China) (1986)

Additional Training

  • Johns Hopkins University School of Medicine, Division of Gastroenterology and Hepatology, Baltimore, MD, Clinical Research Fellow
  • Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, MD, Post-doctoral Fellow

Research & Publications

Research Summary

Our research projects focus on sensory afferent neurobiology and nerve-immune interactions in the GI tract. Specifically, we are interested in studying the cellular and molecular mechanisms underlying vagal afferent nerve activation and mast cell activation-induced sensitization of vagal nociceptive afferents in the esophagus.

For research inquiries please contact Dr. Yu via email at [email protected].

Technology Expertise Keywords

Esophageal Physiology, Vagal Afferent Neurobiology, and Mast Cell Biology

Selected Publications

View all on PubMed

Hu Y, Liu Z, Yu X, Pasricha PJ, Undem BJ, Yu S. Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G149-57

Yu X, Hu Y, Yu S. Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15;307(4):G471-8

Yu X, Yu M, Liu Y, Yu S. TRP channel functions in the gastrointestinal tract. Semin Immunopathol. 2016 May;38(3):385-96

Yu X, Hu Y, Yu M, Undem BJ, Yu S. Deoxycholic acid activates and sensitizes vagal nociceptive afferent C-fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2021 Aug 1;321(2):G149-G156

Patil MJ, Huang Y, Yu M, Dong X, Undem BJ, Yu S. Ginger Constituent 6-Shogaol Attenuates Vincristine-Induced Activation of Mouse Gastroesophageal Vagal Afferent C-Fibers. Molecules. 2022 Nov 2;27(21):7465

Contact for Research Inquiries

Email me Phone: 410-502-2455

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