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Stephen Joseph Meltzer, M.D.

Headshot of Stephen Joseph Meltzer
  • Professor of Medicine

Languages: English, French, German


Abdominal Pain, Barrett's Esophagus, Bloating, Burping Belching, Celiac Disease, Chest Pain, Clinical Gastroenterology, Digestive Disorders, Diverticulitis, Eosinophilic Esophagitis, Gallbladder Diseases, Gallstones, Gas, Gastroenterology, Heartburn, Hiccups, Hoarseness, Indigestion, Malabsorption, Rectal Bleeding, Reflux and Burning, Stomach Pain, Stomach Ulcer, Swallowing Disorders, Weight Loss more

Research Interests

Molecular pathophysiology and translational research in Barrett’s esophagus-associated neoplastic progression more

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Appointment Phone: 410-933-7495
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map


Dr. Stephen J. Meltzer is a Professor of Medicine and Oncology at Johns Hopkins University, Division of Gastroenterology. He is the Director of GI Early Detection Biomarkers Laboratory and a member of the Johns Hopkins Kimmel Cancer Center. His research interests are Gastrointestinal cancer and precancer biomarker discover, development and validation; genomics, epigenomics and bioinformatics, early detection of cancer, outcomes research in cancer and precancer, risk stratification prediction in cancer and precancer, Barrett's esophagus, inflammatory bowel disease-associated cancer, liver cancer and gastric cancer. After receiving degree in Medicine at the State University of New York Medical School, Dr. Meltzer interned at Tulane University in New Orleans and University of Texas Medical Branch in Galveston, TX. He completed his fellowship training program in the University of Colorado and the Lenox Hill Hospital. He was an Assistant Professor in UCLA, Center for Health Science in 1987. Prior to joining the faculty at Johns Hopkins in 2006, he was Professor of Medicine and Pharmacology, Founder and Head of Aero digestive Cancer/Biomarker Program in School of Medicine, University of Maryland at Baltimore. He is an Associate Editor of Cancer Research and a member of the editorial board of Esophageal. He has published 152 original scientific papers in high-impact scientific journals. He also has 43 chapters, review articles, editorials, or letters to the editor; 1 book; and 139 abstracts to his name. He has given a plethora of invited lectures around the world, all involving his principal field of esophageal and gastrointestinal cancer research. He has been the recipient of numerous prestigious national and international awards, including the Robert and Sally D. Funderburg Award in Gastric Cancer Biology and membership in the American Society for Clinical Investigation.

Special Interests: Gastrointestinal cancer and precancer biomarker discover, development and validation; genomics, epigenomics and bioinformatics, early detection of cancer, outcomes research in cancer and precancer, risk stratification prediction in cancer and precancer. Barrett's esophagus, inflammatory bowel disease-associated cancer, liver cancer, gastric cancer more


  • Professor of Medicine
  • Professor of Oncology

Departments / Divisions

Centers & Institutes



  • MD; SUNY at Buffalo School of Medicine (1979)


  • Internal Medicine; University of Texas Medical Branch School of Medicine (1982)


  • Gastroenterology; Lenox Hill Hospital (1985)
  • Gastroenterology; University of Colorado Health Sciences Center (1984)

Board Certifications

  • American Board of Internal Medicine (Gastroenterology) (1985)
  • American Board of Internal Medicine (Internal Medicine) (1982)

Research & Publications


Lab Website: GI Biomarkers Laboratory

Selected Publications

View all on PubMed

Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas KT Wilson, S Fu, KS Ramanujam, SJ Meltzer Cancer Research 58 (14), 2929-2934

Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. RF Souza, R Appel, J Yin, S Wang, KN Smolinski, JM Abraham, TT Zou, ... Nature genetics 14 (3), 255

PTEN1 is frequently mutated in primary endometrial carcinomas D Kong, A Suzuki, TT Zou, A Sakurada, LW Kemp, S Wakatsuki, ...Nature genetics 17 (2), 143-144

Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma K Kawakami, J Brabender, RV Lord, S Groshen, BD Greenwald, ... Journal of the National Cancer Institute 92 (22), 1805-1811

Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. RF Boynton, PL Blount, J Yin, VL Brown, Y Huang, Y Tong, T McDaniel, ... Proceedings of the National Academy of Sciences 89 (8), 3385-3388

Videos & Media

Recent News Articles and Media Coverage

Johns Hopkins Developing New Test for Esophageal Cancer, Inside Tract (Spring 2019)

Trouble on Line-1, Inside Tract (Winter 2016)

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