The David Celentano Lab studies behavioral and social epidemiology by integrating behavioral science theory and research with epidemiology methods. Our team directs epidemiological investigations and stages preventive interventions targeting HIV/AIDS and other sexually transmitted infections.

The David Dowdy Lab conducts research in the field of infectious disease epidemiology. We use an interdisciplinary approach that involves infectious disease modeling, health economics, classical epidemiology, and operational and implementation science. Much of our work explores the diagnosis and treatment of tuberculosis. We also have a longstanding interest in “translational epidemiology,” with a goal of developing methods to help medical professionals who use epidemiological data make decisions that are in the best interest of patients and public health.

The David Graham Lab studies the consequences of HIV interactions with the immune system, the resulting pathogenesis and how to sabotage these interactions. We apply advanced technologies like mass spectrometry to dissect processes at the molecular level. We are also actively involved in cardiovascular research and studies the ways proteins are organized into functional units in different cell types of the heart. Major projects in our lab are organized into three major areas: (1) H/SIV pathogenesis and neuropathogenesis, (2) Cardiovascular disease, and (3) High technology development

Research in the David Hager Lab focuses on critical care medicine. Recent studies includes an analysis of advances in the management of the acute respiratory distress syndrome (ARDS) and the development of a targeted real-time early warning score predicting septic shock. Other interests include ventilator-induced lung injury and high-frequency ventilation.

The David Linden Laboratory has used both electrode and optical recording in cerebellar slice and culture model systems to explore the molecular requirements for induction and expression of these phenomena. Along the way, we discovered a new form of plasticity. In addition, we have expanded our analysis to include use-dependent synaptic and non-synaptic plasticity in the cerebellar output structure, the deep nuclei. Our investigations are central to understanding the cellular substrates of information storage in a brain area where the behavioral relevance of the inputs and outputs is unusually well defined. In addition, our investigations have potential clinical relevance for cerebellar motor disorders and for disorders of learning and memory generally.

Research in the Donald MacGlashan Laboratory aims to understand the regulation of secretion from human basophils and mast cells—two cells thought to play key roles in allergic reactions and other diseases. The hallmark reaction in these cells is degranulation through cell-bound IgE. Our interests lie in the signaling mechanisms that control this dramatic cell response and the factors that regulate the degree of the reaction.

Research in the David Moller Lab focuses on sarcoidosis, a potentially fatal inflammatory disease characterized by tiny clumps of inflammatory cells that scar the lungs, lymph nodes, skin and other major organs. We’re currently involved in a clinical trial related to genomic research in sarcoidosis and a clinical trial related to genomic research in Alpha-1 antitrypsin deficiency. Previously, we led a project that identified a potential protein trigger responsible for sarcoidosis.

Research in the David Sack Lab focuses on enteric infections. Our team has worked to develop laboratory detection methods to better understand the epidemiology of these agents. We also work to create appropriate clinical management strategies, such as antibiotics and rehydration methods, for enteric infections. Our work has included participating in the development of vaccines for a range of bacterial infections, including rotavirus, cholera and enterotoxigenic E. coli.

Areas of research in the David Shade Lab include data-management methods for clinical research, design and conduct of clinical trials, and internet usage for data acquisition and distribution.

Research in the David Sullivan Lab focuses on malaria, including its diagnosis, treatment, molecular biology as it relates to iron, and pathology as it relates to severe anemia. We test and develop new malaria diagnostics — from real-time polymerase chain reaction (PCR) to novel urine and saliva detection platforms. This includes the adaptation of immuno-PCR (antibody coupled to DNA for PCR detection) to malaria and a lead blood stage drug that contains a quinine derivative used to treat malaria in the 1930s.