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School of Medicine
Risk Factors for Women
Sex differences in diabetes and risk of incident coronary artery disease in healthy young and middle-aged adults
Kalyani RR, Lazo M, Ouyang P, Turkbey E, Chevalier K, Brancati F, Becker D, Vaidya D
Generally, women are at far less risk for coronary artery disease than men, but research suggests that a woman’s risk increases fourfold if she has diabetes, making it roughly equal to male risk.
Preeclampsia and hypertensive disease in pregnancy: their contributions to cardiovascular risk
Valdiviezo C, Garovic VD, Ouyang P
Women who experience cardiovascular complications during pregnancy, such as preeclampsia and high blood pressure, may be at an increased risk for cardiovascular disease later in life. These women could benefit from prevention strategies and monitoring.
Risk Factors for Men
Anger in young men and subsequent premature cardiovascular disease: the precursors study
Chang PP, Ford DE, Meoni LA, Wang NY, Klag MJ
Young men who respond to stress with anger are three times more likely to develop premature heart disease. Professional anger management could help these men better manage their stress and, in the process, help protect them from heart disease.
Sleep-disordered breathing and mortality: a prospective cohort study
Punjabi NM, Caffo BS, Goodwin JL, Gottlieb DJ, Newman AB, O'Connor GT, Rapoport DM, Redline S, Resnick HE, Robbins JA, Shahar E, Unruh ML, Samet JM
Sleep apnea is associated with increased rates of coronary artery disease and death, especially in men between 40 and 70. Treating this common sleep disorder could improve heart health and longevity.
Low-risk lifestyle, coronary calcium, cardiovascular events, and mortality: results from MESA
Ahmed HM, Blaha MJ, Nasir K, Jones SR, Rivera JJ, Agatston A, Blankstein R, Wong ND, Lakoski S, Budoff MJ, Burke GL, Sibley CT, Ouyang P, Blumenthal RS
A combination of regular exercise, a healthy diet, smoking avoidance and weight maintenance have been found to beneficially influence coronary calcium levels, calcium progression and overall mortality.
The effects of carbohydrate, unsaturated fat, and protein intake on measures of insulin sensitivity: results from the OmniHeart trial
Gadgil MD, Appel LJ, Yeung E, Anderson CA, Sacks FM, Miller ER 3rd
“Mediterranean diet” foods rich in unsaturated fats, such as avocados, olive oil and nuts, may improve insulin sensitivity, which boosts cardiovascular health and wards off diabetes.
Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis
Silverman MG, Blaha MJ, Krumholz HM, Budoff MJ, Blankstein R, Sibley CT, Agatston A, Blumenthal RS, Nasir K
Coronary calcium scans allow doctors to more accurately assess heart disease risk, especially in those who were thought to be at either very low or very high risk of heart events. These scans offer a more nuanced look at a person’s individual risk.
Friedewald-estimated versus directly measured low-density lipoprotein cholesterol and treatment implications
Martin SS, Blaha MJ, Elshazly MB, Brinton EA, Toth PP, McEvoy JW, Joshi PH, Kulkarni KR, Mize PD, Kwiterovich PO, Defilippis AP, Blumenthal RS, Jones SR
An equation used to calculate low-density lipoprotein (LDL) cholesterol underestimates it when levels of triglyceride are high. People with high triglyceride levels are at risk for cardiovascular complications, so a miscalculation is especially worrying.
Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile
Martin SS, Blaha MJ, Elshazly MB, Toth PP, Kwiterovich PO, Blumenthal RS, Jones SR
The current method of estimating low-density lipoprotein (LDL) cholesterol may be flawed. A new way of calculating LDL cholesterol would enable more accurate risk assessment and a better way of quantifying heart health.