Single or Multi-Center Epidemiologic Databases
Diabetes Prevention Program (DPP)
Multi-center trial aims to test behavioral and pharmacologic interventions to prevent diabetes and diabetes-related vascular disease in 3,600 adults with impaired glucose tolerance.
The DPP Collaborative Group was funded to conduct continued follow-up of the DPP cohort for an additional five years to evaluate the effects of the interventions on further development of diabetes and diabetes complications, including retinopathy, microangiopathy, and cardiovascular disease.
Look AHEAD
Look AHEAD (Action For Health in Diabetes) is a multi-center randomized clinical trial to examine the effects of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and exercise. The trial has completed enrollment of 5,145 obese patients with type 2 diabetes. They will be followed for a total period of up to 11.5 years. The primary aim of Look AHEAD is to study the effects of the two interventions on major cardiovascular events: heart attack, stroke and cardiovascular-related death.
Project Sugar
A randomized, controlled trial with 4 parallel arms sought to determine the benefits of behavioral interventions on control of CVD risk factors in 186 urban African Americans with type 2 diabetes. The 3 intervention arms are: a) Nurse-Case Manager intervention, b) Community Health Worker intervention, c) Combined NCM-CHW intervention, which were compared to usual care alone.
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Project Sugar 2
A randomized controlled trial was designed to test the hypothesis that a primary-care-based NCM plus CHW team approach is an effective, practical, and economically feasible strategy for translating current knowledge about type 2 diabetes into high-quality health care for urban African-Americans. Participants were randomized t a) usual medical care plus minimal telephone intervention implemented by a trained lay health educator (control group) or b) usual medical care plus intensive intervention implemented by a nurse case manager (NCM)/community health worker (CHW) team. A total of 542 urban African-Americans with type 2 diabetes were enrolled and followed for 3 years.
Atherosclerosis Risk in Communities (ARIC)
A multi-center, prospective cohort study of risk factors for Atherosclerosis. Included were 11,475 whites and 4,260 African-Americans aged 45-64 at baseline (1986-89).
The Cardiovascular Health Study (CHS)
A multi-center, observational, population based study of risk factors for cardiovascular disease and stroke among men and women 65 and older. The study enrolled 5,201 men and women in four U.S. communities.
The Sleep Heart Health Study (SHHS)
SHHS is a multi-center cohort study of the cardiovascular consequences of sleep-disordered breathing (SDB). The SHHS has collected high quality polysomnography (PSG) data obtained in the home from 6,440 participants.
Multi-Ethnic Study of Atherosclerosis (MESA)
The major goals of this project are to determine characteristics related to the progression of subclinical to clinical cardiovascular disease. A diverse and representative sample of approximately 7,000 men and women aged 45 to 84 without clinical history or symptoms of coronary artery disease were recruited from six field centers.
Population-based studies in Washington County, Maryland. CLUE I collected 25,802 specimens in 1974-1975. CLUE II was conducted in 1989 and a total of 32,898 persons participated. CLUE II participants have been sent periodic follow-up questionnaires to collect more in-depth health-related information, including health behaviors and updated medical histories.
Choices for Healthy Outcomes in Caring for ESRD (CHOICE)
Initiated in 1995 to examine the impact of dialysis modality, patient preferences and management choices on the outcomes and costs of care. CHOICE recruited 923 participants (80% on hemodialysis, 20% on peritoneal dialysis), 895 of whom have participated in the specimen bank.
African-American Study of Kidney Disease and Hypertension (AASK)
A multi-center, randomized trial to test the effects of two levels of blood pressure control and three different anti-hypertensive regimens on the progression of renal insufficiency in 1,094 African-Americans with hypertension-related renal disease.
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Continuation of AASK
The Continuation of AASK Cohort Study will be followed at the clinical centers. The patients will be provided with the usual clinical care given to all such patients at the respective centers. Baseline demographic information, selected laboratory tests, and other studies are being obtained at the initiation of the Continuation Study.
Chronic Renal Insufficient Cohort (CRIC)
Multi-center cohort study of 3,000 persons, ages 21 to 74, with mild to moderate chronic renal insufficiency. The hypotheses are that a set of nontraditional risk factors is associated with a) progression of chronic renal insufficiency and b) cardiovascular disease and measures of cardiovascular disease progression.
Dietary Approaches to Stop Hypertension (DASH)
A multi-center, randomized feeding study that tested the effects on blood pressure of whole dietary patterns in 459 persons with high normal or Stage 1 hypertension.
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Dietary Approaches to Stop Hypertension 2 (DASH2)
A randomized feeding study that will test the impact on blood pressure of three levels of salt intake in two dietary patterns. The study population includes 400 persons with above optimal blood pressure and Stage 1 hypertension.
A randomized trial that tested the impact on blood pressure of 2 comprehensive lifestyle intervention programs in comparison to a traditional, information-oriented advice program. The study population included 800 persons with above optimal blood pressure or Stage 1 hypertension (systolic BP: 120-159 and diastolic BP of 80-95).
Weight Loss Maintenance (WLM)
A multi-center, randomized, controlled trial to determine the effects of two innovative behavioral interventions. Overweight and obese individuals who are taking medication for hypertension, dyslipidemia and/or type 2 diabetes entered a 6-month, weight loss program. Those 800 individuals who lose at least 4 kg (approximately 9 pounds) were randomized into one of three groups: a Personal Contact (PC) Intervention primarily via telephone; an Interactive Technology (IT) Intervention that provides frequent contacts through a state-of-the-art interactive web-based program supplemented by other communication technologies; or Usual Care (UC). The primary outcome will be weight change from the end of the initial weight loss program to the end of the 30-month weight maintenance intervention period.
The Johns Hopkins Precursors Study
This is a prospective longitudinal study of 1,337 medical students in the classes of 1948-64. The study was initiated in 1947 and has conducted annual follow-up ever since. As such, it is one of the longest continuously functioning studies of its kind. In addition to information on over 6,000 variables at baseline, a multitude of data is available over follow-up, including morbidity and mortality.
Sibling and Family Heart Study
Studies of families where there has been a coronary heart problem at a young age (< 60), begun in 1982, founded by Dr. Diane Becker. Families were enrolled from nine Baltimore Hospitals and come from all over the United States, with some families from Bermuda, Greece, Egypt, Morocco, Sweden, and Great Britain. The studies are moving into the next generation in the same families includes: GeneSTAR, Family Heart Follow-up, G Cal Calcium and Genetics.
Old Order Amish Cohort
Old Order Amish of Lancaster County includes genetically homogenous people; the descendants of a small group of individuals who immigrated to the United States from Europe in the mid-1700s. The cohort includes large families, detailed genealogical records, common lifestyle study the effects of genes and lifestyle on heart disease, longevity and diabetes.