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Simon C. Mathews, M.D.

Simon Mathews

Dr. Mathews leads efforts in clinical innovation at the Johns Hopkins Armstrong Institute for Patient Safety and Quality. He is focused on transforming hospitals and health systems into highly reliable organizations that excel in delivering high quality care. He works closely on strategic initiatives at AI including the development of learning health care systems, expansion of governance structures for quality and safety and collaborations with strategic partners including Johns Hopkins University Applied Physics Lab and Ernst & Young. In addition, he works clinically in the Division of Gastroenterology at Johns Hopkins where he is immersed in quality and safety efforts. He earned his medical degree at the Johns Hopkins School of Medicine and completed his clinical training in Internal Medicine and Gastroenterology at Johns Hopkins. Prior to his medical training he also worked briefly in investment banking at Goldman Sachs in New York City. He is a graduate of the University of Virginia where he studied economics as a Jefferson Scholar.


Physician autonomy and informed decision making: finding the balance for patient safety and quality.
Mathews S.C.
, Pronovost P.J..
JAMA. 2008; 300(24):2913-5.
PMID: 19109120

Bridging the divide: Medical training and the business of medicine
Mathews S.C.
Medical innovation & business. 2010; 2(4):20-21.

A national study examining emergency medicine specialty training and quality measures in the emergency department.
Mathews S.C., Kelen G.D., Pronovost P.J., Pham J.C.
American journal of medical quality : the official journal of the American College of Medical Quality. 2010; 25(6):429-35.
PMID: 20716690

An unfortunate change of heart.
Chronister J.D., Mathews S.C., Chow G.V., Marine J.E.
The American journal of medicine. 2011; 124(3):e3-4.
PMID: 20951364

The need for systems integration in health care.
Mathews S.C., Pronovost P.J.
JAMA. 2011; 305(9):934-5.
PMID: 21364143

Focus on quality: an opportunity to execute health care reform.
Mathews S.C., Pronovost P.J., Herzlinger R.E.
American journal of medical quality : the official journal of the American College of Medical Quality. 2011; 26(3):239-40.
PMID: 21138826

Using the Opportunity Estimator tool to improve engagement in a quality and safety intervention.
Duval-Arnould J., Mathews S.C., Weeks K., Colantuoni E., Mukherjee A., Nundy S., Watson S.R., Holzmueller C.G., Lubomski L.H., Goeschel C.A., Pronovost P.J., Pham J.C., Berenholtz S.M.
Joint Commission journal on quality and patient safety. 2012; 38(1):41-7, 1.
PMID: 22324190

Achieving secondary prevention low-density lipoprotein particle concentration goals using lipoprotein cholesterol-based data.
Mathews S.C., Mallidi J., Kulkarni K., Toth P.P., Jones S.R.
PloS one. 2012; 7(3):e33692.
PMID: 22479428

Eradicating central line-associated bloodstream infections statewide: the Hawaii experience. 
Lin D.M., Weeks K., Bauer L., Combes J.R., George C.T., Goeschel C.A., Lubomski L.H., Mathews S.C., Sawyer M.D., Thompson D.A., Watson S.R., Winters B.D., Marsteller J.A., Berenholtz S.M., Pronovost P.J., Pham J.C.
American journal of medical quality: the official journal of the American College of Medical Quality. 2012; 27(2):124-9.
PMID: 21918016

Commentary: establishing safety and quality as core values: a hospital road map.
Mathews S.C., Pronovost P.J.
American journal of medical quality : the official journal of the American College of Medical Quality. 2012; 27(4):348-9.
PMID: 22205770

Mortality among marathon runners in the United States, 2000-2009.
Mathews S.C., Narotsky D.L., Bernholt D.L., Vogt M., Hsieh Y.H., Pronovost P.J., Pham J.C.
The American journal of sports medicine. 2012; 40(7):1495-500.
PMID: 22562789

25-Year summary of US malpractice claims for diagnostic errors 1986-2010: an analysis from the National Practitioner Data Bank.
Saber Tehrani A.S., Lee H., Mathews S.C., Shore A., Makary M.A., Pronovost P.J., Newman-Toker D.E..
BMJ quality & safety. 2013; 22(8):672-80.
PMID: 23610443

Decreasing central-line-associated bloodstream infections in Connecticut intensive care units.
Hong A.L., Sawyer M.D., Shore A., Winters B.D., Masuga M., Lee H., Mathews S.C., Weeks K., Goeschel C.A., Berenholtz S.M., Pronovost P.J., Lubomski L.H.
Journal for healthcare quality : official publication of the National Association for Healthcare Quality. 2013; 35(5):78-87.
PMID: 23347278

Eliminating central line-associated bloodstream infections: a national patient safety imperative.
Berenholtz S.M., Lubomski L.H., Weeks K., Goeschel C.A., Marsteller J.A., Pham J.C., Sawyer M.D., Thompson D.A., Winters B.D., Cosgrove S.E., Yang T., Louis T.A., Meyer Lucas B., George C.T., Watson S.R., Albert-Lesher M.I., St Andre J.R., Combes J.R., Bohr D., Hines S.C., Battles J.B., Pronovost P.J..
Infection control and hospital epidemiology. 2014; 35(1):56-62.
PMID: 24334799

Mining high-dimensional administrative claims data to predict early hospital readmissions.
He D., Mathews S.C., Kalloo A.N., Hutfless S.
Journal of the American Medical Informatics Association : JAMIA. 2014; 21(2):272-9.
PMID: 24076748 PMCID: PMC3932470

Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia.
Mathews S.C., Ciarleglio M., Chavez Y.H., Clarke J.O., Stein E., Chander Roland B.
World journal of clinical cases. 2014; 2(9):448-54.
PMID: 25232548 PMCID: PMC4163767

Management's Discussion and Analysis: A tool for advancing quality and safety.
Mathews S.C., Demski R., Pronovost P.J.
Healthcare (Amsterdam, Netherlands). 2016; 4(3):129-31.
PMID: 27637813

Redefining Accountability in Quality and Safety at Academic Medical Centers.
Mathews S.C., Demski R., Pronovost P.J.
Quality management in health care. 2016; 25(4):244-247.
PMID: 27749723

A Model for the Departmental Quality Management Infrastructure Within an Academic Health System.
Mathews S.C., Demski R., Hooper J.E., Biddison L.D., Berry S.A., Petty B.G., Chen A.R., Hill P.M., Miller M.R., Witter F.R., Allen L., Wick E.C., Stierer T.S., Paine L., Puttgen H.A., Tamargo R.J., Pronovost P.J.
Academic medicine: journal of the Association of American Medical Colleges. 2017; 92(5):608-613.
PMID: 27603038

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