In This Section      
 

Radiological Physics Division

The Radiological Physics Division (RPD) was initially established in July 2002 as the Division of Medical Imaging Physics (DMIP) with the recruitment of Benjamin Tsui and his 14 associates — in 2018, George Sgouros became director of the division.  It was rebranded as the Radiological Physics Division to expand its mission beyond imaging so that all of radiological physics, including radionuclide therapy is encompassed.

Mission Statements

  • Conduct state-of-the-art research in medical imaging physics, especially in the areas of nuclear medicine, including PET and SPECT, and X-ray imaging, including CT.
  • Establish a graduate degree program in medical imaging physics within the Department of Radiology and Radiological Science.
  • Provide physics education to residents, fellows and technologists.
  • Provide clinical physics support to various clinical divisions of the Department of Radiology and Radiological Science.      
 

Our Research

Preclinical studies

  • Optimize radiopharmaceutical therapy (RPT).
  • RPT dose and response modeling.
  • Alpha-emitter RPT (αRPT), in vivo RBE evaluation in collaboration with Radiation Oncology SARRP facility.
  • Develop and evaluate agents for alpha-RPT to treat a variety of cancers (breast, liver/liver mets, melanoma).
  • Monolayer and spheroid response to DNA repair modulators with α-emitters.

Clinical Trials

  • Imaging/dosimetry-driven clinical dose escalation trial of Y-90 microsphere therapy
  • Treatment planning-based combination radiotherapy and αRPT for prostate cancer
  • Treatment planning-based combination radiotherapy and radioiodine RPT for thyroid cancer
  • Canine osteosarcoma αRPT trial

Imaging

  • Quantitative imaging and image quality optimization to assess therapeutic response in prostate cancer patients with skeletal metastases.
  • Quantitative SPECT imaging of therapeutic radionuclides, including Ac-225, Ra-223, Pb-212 and Th-227
  • Pediatric nuclear medicine imaging optimization
  • Image-guided intervention and advanced ultrasound imaging to develop ultrasound-guided solutions for a variety of medical conditions.
  • Task-based diagnostic image quality evaluation.
  • Spectral, photon-counting-detector-based CT
  • Acute ischemic stroke imaging using dual-energy CT
  • Motion estimation and compensation for cardiac CT
  • Iterative image reconstruction methods and task-based image quality evaluation for x-ray CT.
  • Helical cone-beam CT
  • Interventional soft tissue perfusion using x-ray system.

In Silico

  • Microscale dosimetry of alpha-emitters.
  • RPT treatment and response simulations to translate preclinical model results towards human trial design optimization.
  • NURBS phantom-based simulation of SPECT/CT imaging of nuclear medicine agents.
  • NURBS phantom-based simulation of CT imaging for improved diagnosis of pancreatic cancer
  • AI-based image reconstruction, quality assessment, response evaluation.

Dosimetry

  • Ongoing development of patient-specific radiobiological dosimetry methods.
  • Clinical trial evaluation of absorbed dose vs response.
  • Uncertainty evaluation for radiopharmaceutical dosimetry chain.

Radiation Safety

  • Develop strategies that better communicate radiation doses and risks with patients and staff.

Contact Information

Radiological Physics Division
Russell H. Morgan Department of Radiology and Radiological Science
Johns Hopkins Medical Institutions
601 N. Caroline St.
JHOC Room 4263
Baltimore, MD 21287

Contact our administrative coordinator:
Phone: 443-287-2425
Fax: 410-614-1060