Man smiling and resting on bicycle
Mind. Medicine. Healing. Hope. advance to content button

Mouse Studies Advance Search for New Class of Antidepressants

Released: February 7, 2019. In experiments with mice, researchers at Johns Hopkins Medicine report a promising advance in the search for a new class of drugs to treat major depression.

A compound developed by the Johns Hopkins Drug Discovery Group targets a chemical in specific cells of the mammalian brain, and eases signs of social avoidance and depression in rodents, without some of the toxic side effects that have bedeviled its parent compound.

Learn more
Featured Video

#TomorrowsDiscoveries: Preventing Obesity


Dr. Susan Carnell and her team are researching ways to treat or prevent obesity more effectively. 

Researchers Higgs, Lema, and Ishizuka

Seeking Knowledge to Cure and Prevent

Our clinical research programs range from efficacy and treatment-response studies to clinical trials and epidemiology. Our basic research encompasses bioinformatics, genetics, neuroscience, neuroimaging, and molecular biology - all in an effort to unlock the causal pathways to the major psychiatric conditions and to use this knowledge to develop practical means to improve diagnosis and treatment.

More on Research
Brain image
Meet Our Experts

Meet Drs. Goes and Zandi

More than 100 years of research on familial bipolar disorder hasn’t revealed much about its specific genetic causes. But all that’s about to change, says psychiatric epidemiologist Peter Zandi thanks to advances in genome data analysis and sequencing—and access to human brain samples to tease out clues. “Our goal,” says psychiatrist Fernando Goes “is to find etiologic clues that will ultimately lead to new, urgently needed, targeted drugs.”

Training fellows meeting around desk

Professional Education

The depth of our clinical expertise and the breadth of our research programs allow us to train the next generation of psychiatrists and scientists to be clinical and research leaders. Our educational programs include medical student education, a general psychiatry residency, a child and adolescent psychiatry residency, and post-doctoral fellowship and research training opportunities.

Training Programs


The John P. Boogher Memorial Lecture
Johns Hopkins Hospital
Elizabeth Ratner Memorial Lecture
Johns Hopkins Hospital


the johns hopkins hospital exterior

The Johns Hopkins Hospital
1800 Orleans St.
Baltimore, Maryland 21287


johns hopkins bayview hospital exterior

The Johns Hopkins Bayview Medical Center
4940 Eastern Ave.
Baltimore, Maryland 21224


sibley hospital exterior

Sibley Memorial Hospital
5255 Loughboro Road, N.W.
Washington, D.C. 20016


howard county hospital exterior

Howard County General Hospital
5755 Cedar Lane
Columbia, Maryland 21044