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Linzhao Cheng

On making stem cells from a patient's blood sample:

Video transcription: "The recent advance of this field is very exciting or even we can say evolutionary. And that is the technology called iPS cells—or the induced pluripotent stem cells. Basically it’s the evolutionary technique, where we can convert the adult cells -- such as skin, such as other cell types -- to the very early primitive stage, the state that would be very similar to the cells isolated or derived from the early embryo, such as embryonic stem cells. They can proliferate, they can be expanded in the laboratory forever, but they can also generate one of the 220 different cell types.

"One contribution that we made to the field is that we can generate iPS cells safer and and cleaner iPS cells from the periphery blood, just from a blood draw, so that we don’t have to use the skin biopsy. Not only does it take shorter time, for example, from 10 days versus four to six weeks, but also we found out that it’s more efficient after we overcome some of the technical hurdles. Since we can derive iPS cells from the patient with a particular type of the disease with a particular type of the mutation, so it’s probably the first time that we can link the human genetics to the human cell biology or biochemistry."