We are also actively recruiting participants for ongoing research studies. The combination of research with clinical practice keeps our clinicians up to date with evidence-based and high-quality practices.

PMDD Biomarker Study (BIO-P Study)

The BIO study at the Johns Hopkins School of Medicine is seeking individuals with regular menstrual cycles to participate in a research study on premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD), which are characterized by mood changes in the week before a menstrual period. This study will investigate differences in DNA methylation patterns between people who have PMS/PMDD and people who do not. We are looking both for women who DO experience premenstrual mood symptoms and women who do NOT experience premenstrual mood symptoms before their periods.

Participants will be able to complete the study entirely at home. Participants will have a remote Baseline visit to determine eligibility that includes questionnaires and an interview. Then, they will complete daily mood ratings for two menstrual cycles. In a third menstrual cycle, participants will be mailed kits to self-collect dried blood spots at 2 time points in the menstrual cycle. Participants can receive compensation up to $305.

To be eligible for the study, participants must:

• Be age 18-50
• Have a regular menstrual cycle
• Not using hormonal birth control
• Not using psychiatric medications
• No history of endocrine disorders
• No regular tobacco use

Be located in the states of Maryland or Virginia

Participants can receive $305 in compensation for completion of the study.

Study Location: Remote

Laboratory Location: Johns Hopkins Reproductive Mental Health Center, 550 North Broadway St., Baltimore, MD 21205

Contact Information: 
Research Assistant: Victoria Seo
Email: [email protected]  / Contact Phone: (302) 464-8320‬
Principal Investigator: Liisa Hantsoo, Ph.D
Protocol#: IRB00484410

For more information and to complete the screening form

The BLOOM Study (Bridging Luteal Ovarian Hormones and Mood)

Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor (SSRI) Responsive Premenstrual Dysphoric Disorder

The Johns Hopkins Reproductive Mental Health Center, at the Johns Hopkins School of Medicine, is seeking individuals with regular menstrual cycles to participate in a research study
on premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD), or mood changes in the week before a menstrual period. This study will also be investigating the effects of anti-
depressants in managing PMS/PMDD.

We are looking both for women who DO experience premenstrual mood symptoms and women who do NOT experience premenstrual mood symptoms before their periods. 

Participants will have 1 remote visit, including mood questionnaires, tracking your menstrual cycle, and providing blood samples. Following the remote visit, there will be 4-8 blood draws
over the span of 1-2 months. 

To be eligible for the study, participants must:

• Be age 18-50
• Have a regular menstrual cycle
• Not be taking hormonal birth control
• Not using psychiatric medications
• Participants can receive between $240 - $380 in compensation for completion of the
  study.

Study Location: Johns Hopkins Reproductive Mental Health Center 550 North Broadway, 21205, Baltimore, MD

Contact Information:
Research Assistant: Victoria Paone
Email: [email protected] Contact Phone: (443)-354-1860
Liisa Hantsoo, Ph.D
Principal Investigator Protocol# IRB00445770
Click here to complete the online screening.

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ENROLLMENT CLOSED: Dietary Fat Intake, BMI, and Stress in Women with Premenstrual Mood Disorders (DIBS): A Perfect Storm for Inflammation?

The Johns Hopkins Reproductive Mental Health Center, at the Johns Hopkins School of Medicine, is seeking individuals with regular menstrual cycles to participate in a research study on mood changes and diet in the week before a menstrual period. This study will be investigating the relationships among diet, mood, and inflammation. We are looking both for women who DO experience premenstrual mood symptoms and women who do NOT experience premenstrual mood symptoms before their periods, and we are looking for women across a range of body mass indexes (BMI)s.

Participants will have a remote screening visit. If eligible, participants will then have 1 remote study visit including mood questionnaires, tracking their menstrual cycle, and providing saliva and stool samples. There will also be 1 in-person study visit that will take around 3 hours to complete.

To be eligible for the study, participants must:

• Be age 18-50
• Have a regular menstrual cycle
• Not be taking hormonal birth control
• Not using psychiatric medications
• No history of endocrine disorders

Participants can receive $100 in compensation for completion of the study.

Study Location: Johns Hopkins Reproductive Mental Health Center 550 North Broadway, 21205, Baltimore, MD
Contact Information:
Research Assistant: Victoria Paone
Email: [email protected], (443)- 354-1860
Principal Investigator: Liisa Hantsoo, Ph.D, IRB00464411

ENROLLMENT CLOSED: A Multicenter, Randomized, Double-Blind, Parallel-Group Dose-Controlled Study Evaluating the Safety and Efficacy of RE104 for Injection in the Treatment of Patients with Postpartum Depression (PPD)

Are you struggling with Postpartum Depression (PPD)?

If you’ve had a baby within the last 15 months and think you may be experiencing postpartum depression, you may be eligible to participate in a paid research study. This study is evaluating whether a single-dose investigational treatment can help reduce PPD symptoms.

To qualify:

• Symptoms must have begun between the second trimester of pregnancy or within four weeks after childbirth.
• Participants must not be breastfeeding or pumping milk.
• Must be between 18 and 45 years old.

Participants may be compensated up to $550 for their time.

Study Location: Johns Hopkins Reproductive Mental Health Center, 550 N. Broadway St., Baltimore, MD, 21205

For more information, please contact:
Research Assistant: Victoria Paone, [email protected] (443)- 354-1860
Principal Investigator: Liisa Hantsoo, Ph.D., IRB00446058