Thrombotic Microangiopathy

Johns Hopkins has assembled a team of physicians and researchers dedicated to the care and management of patients diagnosed with TMA.  This multidisciplinary team draws from Nephrology, Hematology, Transfusion Medicine, Pathology, and Laboratory Medicine.

What type of research into TMA is being conducted at Johns Hopkins?

At present, the Johns Hopkins Complement Associated Disease Registry is currently enrolling individuals with TMA, TMA-predisposing conditions, and complement associated diseases.  This is a clinical registry that collects information, blood, urine, and tissue specimens for ongoing research into mechanisms, diagnosis, and therapy of TMA.

Johns Hopkins is also an enrolling site for the Global aHUS Registry, an international observational registry of individuals diagnosed with aHUS.  This is an anonymous registry designed to help researchers better understand the disease, and it does not involve the administration of any specific treatment.

I have been diagnosed with TMA or a TMA related disease and would like to be seen at Johns Hopkins.

Patients interested in being evaluated at Johns Hopkins should call 410-955-5268 (option #4) to request an evaluation with Dr. C. John Sperati.

C. John Sperati, M.D., M.H.S.

Primary Location: Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center), Baltimore, MD

Selected References:

  1. Sperati CJ and Moliterno AR. Thrombotic microangiopathy: Focus on atypical hemolytic uremic syndrome. Hematol Oncol Clin North Am. 2015;29:541-59.
  2. Gavriilaki E et al. Modified Ham test for atypical hemolytic uremic syndrome. Blood. 2015;125:3637-46.
  3. Licht C et al. The global aHUS registry: methodology and initial patient characteristics. BMC Nephrol. 2015;16:207.