C. John Sperati, M.D., M.H.S.

Christopher John Sperati, M.D., M.H.S.

Headshot of C. John Sperati
  • Director, Nephrology Fellowship Training Program
  • Associate Professor of Medicine


Atherosclerotic Renovascular Disease, Atypical Hemolytic Uremic Syndrome (aHUS), Electrolyte Disorders, Fibromuscular Dysplasia (FMD), Glomerulonephritis, High Blood Pressure (Hypertension), Hyperaldosteronism, Nephrology, Renal Artery Disease ...read more

Research Interests

Fibromuscular Dysplasia; Thrombotic microangiopathy; Atypical hemolytic uremic syndrome ...read more

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Outside of Maryland & Washington D.C.

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Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center)

Appointment Phone: 410-955-0670
601 N. Caroline St.
Baltimore, MD 21287
Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center) - Google Maps


Dr. C. John Sperati is an Associate Professor of Medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include renal medicine. 

Dr. Sperati is Director of the Nephrology Fellowship Training Program and serves as the Firm Faculty Leader of the Barker Firm.  In addition, he co-directs the Johns Hopkins Osler Learning Initiative which brings the principles of medical residency training to executive education worldwide.

He obtained his medical degree from The Pennsylvania State University College of Medicine and a Master in Health Science from the Johns Hopkins Bloomberg School of Public Health. He completed an internship and residency in Internal Medicine at the Johns Hopkins Hospital, followed by a year as an Assistant Chief of Service (chief resident). He subsequently pursued subspecialty training in nephrology at the Johns Hopkins Hospital and joined the faculty in the Division of Nephrology.

Dr. Sperati’s clinical interests are in thrombotic microangiopathy including atypical hemolytic uremic syndrome (aHUS), complement mediated kidney diseases including C3 glomerulopathy, secondary and resistant hypertension (fibromuscular dysplasia, atherosclerotic renal arterial disease, hyperaldosteronism, and genetic hypertensive syndromes), glomerulonephritis (e.g., IgA nephropathy, MPGN), and nephrotic syndromes (e.g., FSGS, membranous, minimal change, amyloidosis, and others).  He is the site principal investigator for several clinical studies, serves on editorial boards, and is a member of the National Kidney Foundation Education Committee as well as the Nephrology Knowledge Check-in Task Force of the American Board of Internal Medicine.  His clinical expertise has been recognized by induction into the Miller Coulson Academy of Clinical Excellence.

This provider is registered with the Florida Department of Health to perform telehealth services for patients in Florida.

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  • Director, Nephrology Fellowship Training Program
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; Penn State College of Medicine (2000)


  • Medicine; Johns Hopkins University School of Medicine (2003)


  • Nephrology; Johns Hopkins University School of Medicine (2004)
  • Nephrology; Johns Hopkins University School of Medicine (2007)

Board Certifications

  • American Board of Internal Medicine (Internal Medicine) (2003)
  • American Board of Internal Medicine (Nephrology) (2007)

Research & Publications

Clinical Trial Keywords

FSGS, IgA, minimal change, membranous, aHUS, hemolytic uremic syndrome, C3 glomerulopathy

Clinical Trials

Cure Glomerulopathy (CureGN) 

A multi-center, randomized, double-blind, placebo-controlled, parallel-group, phase III study to evaluate the efficacy and safety of LNP023 in primary IgA nephropathy patients.

A multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in complement 3 glomerulopathy.

Selected Publications

View all on PubMed

Gavriilaki E, Yuan X, Ye Z, Ambinder AJ, Shanbhag SP, Streiff MB, Kickler TS, Moliterno AR, Sperati CJ, Brodsky RA. “Modified Ham test for atypical hemolytic uremic syndrome.” Blood. 2015 Jun 4;125(23):3637-46. doi: 10.1182/blood-2015-02-629683. Epub 2015 Apr 10.

Sperati CJ, Moliterno AR. “Thrombotic microangiopathy: focus on atypical hemolytic uremic syndrome.” Hematol Oncol Clin North Am. 2015 Jun;29(3):541-59. doi: 10.1016/j.hoc.2015.02.002. Epub 2015 Apr 4.

Sperati CJ, Whaley-Connell A. “Secondary hypertension: beginnings and transitions.” Adv Chronic Kidney Dis. 2015 May;22(3):177-8. doi: 10.1053/j.ackd.2015.03.001.

Vernon HJ, Sperati CJ, King JD, et al. “A detailed analysis of methylmalonic acid kinetics during hemodialysis and after combined liver/kidney transplantation in a patient with mut0 methylmalonic academia.” J Inherit Metab Dis. 2014 Nov; 37(6): 899–907. doi:10.1007/s10545-014-9730-7.

Foy M, Sperati CJ, Lucas GM, Estrella MM. “Drug interactions and antiretroviral drug monitoring.” Curr HIV/AIDS Rep. 2014 Sep;11(3):212-22. doi: 10.1007/s11904-014-0212-1.

Amir A Naderi; Brian A Houston; C John Sperati; All wrapped up and nowhere to flow. The American journal of medicine 2012;125(9):876-9. 2012 

Elizabeth George; Girish N Nadkarni; Michelle M Estrella; Gregory M Lucas; C John Sperati; Mohamed G Atta; Derek M Fine; The impact of hepatitis C coinfection on kidney disease related to human immunodeficiency virus (HIV): a biopsy study. Medicine 2011;90(5):289-95. 2011 

C John Sperati; Michael B Streiff; Acute renal failure in a patient with antiphospholipid syndrome and immune thrombocytopenic purpura treated with eltrombopag. American journal of hematology 2010;85(9):724-6. 2010

C John Sperati; Nada Alachkar; Ronald Rodriguez; Mark Haas; Michael J Choi; Incidental discovery of a renal cell carcinoma on native kidney biopsy. American journal of kidney diseases : the official journal of the National Kidney Foundation 2010;56(1):175-80. 2010

Michelle M Estrella; Chistopher J Sperati; Wen H L Kao; Rulan S Parekh; Genetic epidemiology of chronic kidney disease. Current opinion in nephrology and hypertension 2010;19(3):283-91. 2010

Joshua F Zeidner; Edwin J Ostrin; Emily Sydnor; Derek Fine; C John Sperati; The tissue's the issue. The American journal of medicine 2010;123(5):420-2. 2010

Sayed Tabatabai; C John Sperati; Mohamed G Atta; Kashif Janjua; Christopher Roxbury; Gregory M Lucas; Derek M Fine; Predictors of complication after percutaneous ultrasound-guided kidney biopsy in HIV-infected individuals: possible role of hepatitis C and HIV co-infection. Clinical journal of the American Society of Nephrology : CJASN 2009;4(11):1766-73. 2009

C John Sperati; Rulan S Parekh; Yvette Berthier-Schaad; Bernard G Jaar; Laura Plantinga; Nancy Fink; Neil R Powe; Michael W Smith; Josef Coresh; W H Linda Kao; Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients. American journal of kidney diseases : the official journal of the National Kidney Foundation 2009;53(5):845-55. 2009

C John Sperati; Nisha Aggarwal; Aravind Arepally; Mohamed G Atta; Fibromuscular dysplasia. Kidney international 2009;75(3):333-6. 2009 

Priscilla K Brastianos; Jordan W Swanson; Michael Torbenson; John Sperati; Petros C Karakousis; Tuberculosis-associated haemophagocytic syndrome. The Lancet infectious diseases 2006;6(7):447-54. 2006

C D Collard; A Väkevä; C Büküsoglu; G Zünd; C J Sperati; S P Colgan; G L Stahl; Reoxygenation of hypoxic human umbilical vein endothelial cells activates the classic complement pathway. Circulation 1997;96(1):326-33. 1997

Contact for Research Inquiries

1830 E. Monument St.
Room 416
Baltimore, MD 21287 map
Phone: 410-955-5268
Fax: 410-367-2258

Activities & Honors


  • Fellow, National Kidney Foundation
  • Member, Miller Coulson Academy of Clinical Excellence
  • Distinguished Educator Award, American Society of Nephrology, 2020


  • American Society of Nephrology
  • National Kidney Foundation

Professional Activities

  • Barker Firm Faculty Leader, Osler Medical Residency
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