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Experimental and Computational Genomics Core

The Experimental and Computational Genomics Core is a new Core that integrates all of the Kimmel Cancer Center cancer genomics services. Its primary mission is to help investigators harness the ongoing revolution in cancer genomics to accelerate basic discovery and translational research. The Core provides the services previously offered through the Microarray Core, Next Generation Sequencing Core, and Bioinformatics Core. The new joint structure recognizes that the activities of these Cores are highly interdependent and formalizes a longstanding commitment to coordinate computing resources, hiring, and educational activities. It offers streamlined access to experimental and computational genomics technologies and expertise and enhanced opportunities for didactic and hands-on education in the experimental and computational aspects of cancer genomics. The integrated cross-disciplinary Core brings together immense laboratory and analytical expertise that is not readily accessible via outside resources.

The Core provides state-of-the-art next generation sequencing and microarray technologies and analytical workflows for:

  • probing genomic alterations (including SNVs, indels, structural alterations)
  • cancer epigenomics (e.g. ChIP-seq, DNA methylome)
  • transcriptomics
  • metagenomics

For each project, the Core uses a multidisciplinary clinic model to establish and execute an experimental and analytical plan, assisting in all aspects of genomics experiments, including:

  • experimental design
  • high throughput microarray or next generation sequencing workflows
  • computational/bioinformatics data analysis.

Extensive educational resources are also provided, including short courses, workshops, and a symposium that helps investigators fully understand and utilize the data and analyses generated. The Core has heavy usage across all Research Programs.

Stephen Baylin, M.D.

Senior Advisor

Contact

Phone: 443-287-7341