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Jorge Escalante-Semerena, Ph.D.

Jorge Escalante-Semerena, Ph.D. Jorge Escalante-Semerena, Ph.D.

Key Publications

Garrity J, Gardner JG, Hawse W, Wolberger C, Escalante-Semerena JC. (2007). N-lysine propionylation controls the activity of propionyl-CoA synthetase. J Biol Chem. 282(41), 30239-30245.  PubMed Link

Gardner JG, Grundy FJ, Henkin TM, Escalante-Semerena JC. (2006). Control of acetyl-coenzyme A synthetase (AcsA) activity by acetylation/deacetylation without NAD(+) involvement in Bacillus subtilis. J Bacteriol. 188(15), 5460-5468.  PubMed Link

Starai VJ, Garrity J, Escalante-Semerena JC. (2005). Acetate excretion during growth of Salmonella enterica on ethanolamine requires phosphotransacetylase (EutD) activity, and acetate recapture requires acetyl-CoA synthetase (Acs) and phosphotransacetylase (Pta) activities. Microbiology. 151, 3793-3801.  PubMed Link

Starai VJ, Gardner JG, Escalante-Semerena JC. (2005). Residue Leu641 of acetyl-CoA synthetase (Acs) is critical for the acetylation of residue Lys609 by the protein acetyltransferase (Pat) enzyme of Salmonella enterica. J. Biol. Chem. 280, 26200-26205.  PubMed Link

Starai VJ, Escalante-Semerena JC. (2004). Identification of the protein acetyltransferase (Pat) enzyme that acetylates acetyl-CoA synthetase in Salmonella enterica. J. Mol. Biol. 340, 1005-1012.  PubMed Link

Starai VJ, Takahashi H, Boeke JD, Escalante-Semerena JC. (2004). A link between transcription and intermediary metabolism: a role for Sir2 in the control of acetyl-CoA synthase. Curr. Op. Microbiol. 7(2), 115-119.  PubMed Link

Starai VJ, Escalante-Semerena JC. (2004). Acetyl-coenzyme A synthetase (AMP-forming). Cell. Molec. Life Sci. 61, 2020-2030.  PubMed Link

Starai VJ, Takahashi H, Boeke JD, Escalante-Semerena JC. (2003). Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 function in Salmonella enterica and Saccharomyces cerevisiae. Genetics. 163, 545-555.  PubMed Link

Starai VJ, Celic I, Cole RN, Boeke JD, Escalante-Semerena JC. (2002). Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science. 298, 2390-2392.  PubMed Link

Smith JS, Brachmann CB, Celic I, Kenna MA, Muhammad S, Starai VJ, Avalos J, Escalante-Semerena JC, Grubmeyer C, Wolberger C, Boeke JD. (2000). A phylogenetically conserved NAD+-dependent protein deacetylase in the Sir2 protein family. Proc. Natl. Acad. Sci. USA. 97, 6658-6663.  PubMed Link

Tsang AW, Escalante-Semerena JC. (1998). CobB, a new member of the SIR2 family of eukaryotic regulatory proteins is required to compensate for the lack of nicotinate:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2. J. Biol. Chem. 273, 31788-317944.  PubMed Link

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