The Epigenetics Center of the Institute for Basic Biomedical Sciences is bringing together an outstanding team of multidisciplinary investigators to explore the epigenetic basis of normal development and disease. One of the Center’s major goals is to develop novel technology that will provide cutting edge tools to the Hopkins community allowing our scientists to make the first discoveries in this exciting frontier.
Understanding how the information in the human genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself and the proteins that organize eukaryotic DNA into chromatin. This form of gene regulation, termed epigenetics, refers to cellular "memory" other than the DNA sequence alone, and occurs through mechanisms involving chromatin modification and remodeling.