Coordinated Services for Metabolism Research

Coordinated Services for Metabolism Research (CSMR) features a 600-square-foot laboratory with ventilated housing for mice, CLAMS and Oxymax open-flow indirect calorimeters, and associated or additional services to measure food and fluid intake, physical activity, glucose homeostasis and behavioral outcomes. CSMR also offers indirect calorimetry during treadmill exercise, with alternative ambient temperatures and photoperiods. The service core is managed by Susan Aja, Ph.D., who provides project management, conducts studies, provides expertise for in vivo approaches to metabolism and obesity research, and refers researchers to CSMR and other facilities and personnel with appropriate equipment and expertise to support metabolic research. CSMR has been supporting projects in energy balance and metabolism since 2008.


Please see our CSMR Services Menu for specific offerings and prices. Contact Susan Aja for more information and to initiate a project.  for specific offerings and prices. Contact Susan Aja for more information and to initiate a project. 

Project Management

Researchers interested in CSMR services should contact the core early in the process. Indirect calorimetry, other tests, and housing rodents in the CSMR facility all require Johns Hopkins University Animal Care and Use Committee (ACUC) approval, and early engagement ensures optimal scheduling. 

Projects at CSMR always begin with a consultation meeting to discuss: 

  • Study background, preliminary data and other observations
  • CSMR services that meet study objectives
  • Experimental design
  • Coordinating with other cores and laboratories as needed
  • Cohorts, ages, sexes, genotypes, known phenotypes, diets and treatments
  • Guidelines, literature, best practices and issues in the field
  • Timelines, deadlines and other objectives
  • Budget, cost estimates and billing procedures

Next, to initiate the project, researchers must obtain ACUC approval of an amendment to use the core and request animal transfer (both templates provided by core). An active budget number must be provided (or identify alternative forms of payment if at a different institution). 

During the project, CSMR provides aid with animal transfers, arranging body composition data (Phenotyping Core), conducting tests, data processing and analysis. 

Finally, researchers will attend a close-out meeting during which the data will be reviewed, discussed and used to inform potential future actions. Billing is performed on a rolling monthly basis as projects are conducted successfully and data provided. Researchers are welcome to contact CSMR anytime for additional follow-up discussions and assistance with manuscripts or grant applications.