Understand the factors that underlie the pathobiology of COVID-19, the progression to severe illness or death, and the effectiveness of therapeutic interventions in order to provide personalized care to patients infected with SARS-CoV-2.


Improve the care of patients infected with SARS-CoV-2 by learning about COVID-19 pathobiology, likelihood of disease progression and impact of specific therapeutic interventions. We aim to provide this information to clinicians, patients and family members at the point of care.

COVID-19 Research and Precision Medicine

The research aims that inform us on how to best care for patients include:

COVID-19 Disease Trajectory

Characterize the longitudinal trajectories of patients infected with SARS-CoV-2 to inform research questions and clinical care.

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Prediction Modeling

Develop prediction models of COVID-19 severe disease and death that can be used at the point of care to inform treatment decisions, resource allocation and discussions with patients and families.


Effectiveness of Therapeutic Interventions

Examine the impact of different treatment interventions on COVID-19 outcomes.


Racial and Social Inequities

Explore racial and social inequities in COVID-19 diagnosis and management.

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Developed by Our Team

COVID-19 Precision Medicine Analytics Platform Registry (JH-CROWN)

Johns Hopkins has created the JH-CROWN registry to gather information on all of the patients who have been seen at our health system with suspected or confirmed COVID-19. It will be used to learn about the pathobiology of COVID-19 and to better understand patient outcomes.

COVID Inpatient Risk Calculator (CIRC)

The COVID Inpatient Risk Calculator (CIRC) uses factors on admission to the hospital to predict the likelihood that a patient admitted with COVID-19 will progress to severe disease or death within 7 days of arrival. We are excited that it is now also available on MDCalc.

Severe COVID-19 Adaptive Risk Predictor (SCARP)

The COVID-19 adaptive risk predictor (SCARP) is a tool that calculates the 1-day and 7-day risk of progression to severe disease or death for adult patients (18 years and older) who are hospitalized with COVID-19.

Coronavirus Research

Johns Hopkins Medicine researchers are working tirelessly to find ways to better understand, treat and eventually eliminate COVID-19 and the illness that results from infection. In addition, Johns Hopkins researchers are conducting a variety of clinical trials to find new ways to detect, prevent and treat COVID-19.

Patient Care for COVID-19 

The Johns Hopkins biocontainment unit is a state-of-the art-facility designed to care for patients affected by high-consequence infectious diseases such as COVID-19. The unit is a multidisciplinary collaboration of experts from across the Johns Hopkins Health System and around the world. Find out more about the biocontainment unit.