Amita Gupta, M.D., M.H.S.

Lab

Lab Website: Amita Gupta Lab

Clinical Trial Keywords

Tuberculosis; HIV; PMTCT; Breastfeeding; Antiretroviral; MDR-TB; Maternal and Infant Health

Clinical Trials

• ACTG 5273: Multicenter Study of Options for Second-Line Effective Combination Therapy (SELECT)


• ACTG 5274: Phase IV, Open Label Strategy Trial: REMEMBER: Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment Regimens


• ACTG 5300/IMPAACT 2003: Phase III, Open Label, Multi-center Trial: Protecting Households on Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients


• IMPAACT 2026: Pharmacokinetic Properties of Antiretroviral and Anti-tuberculosis Drugs during Pregnancy and Post-partum


• IMPAACT 1077B/1077FF: Promoting Maternal and Infant Survival Everywhere (PROMISE): Breastfeeding and Formula Feeding Versions


• IMPAACT 1078: Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings


• IMPAACT 2005: A Phase I/II Open-Label, Single-Arm Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Delamanid in Combination with OBR for MDR-TB in HIV-Infected and Uninfected Children with MDR-TB


• The Pharmacokinetics, Safety and Acceptability of New Child-Friendly Formulations of Clofazimine and Moxifloxacin in Children Routinely Treated for Rifampicin-Resistant Tuberculosis (CATALYST)


• Epidemiologic Factors Associated with TB Treatment Outcomes Across RePORT International Consortia


• Dynamics and Immune Mechanisms of QFT Response in Close Contacts of TB Cases


• A Nanopore Biosensor for Leveling MTB  Antigens in Blood


• Effect of Neighborhoods and Peer Networks on Substance Use and Violence Among Adolescents Living with and Without HIV in India


• Impact of Tuberculosis Infection on HIV-1 Antibody Response (NWCS501)


• Pharmacokinetic Assessment of MDR-TB Drugs in the Treatment of TB Meningitis


• Identification of Biomarkers That Can Predict Progression from Latent Tuberculosis Infection to Active Tuberculosis Disease


• Tuberculosis (TB) Aftermath


• Mental Health Outcomes among Health Care Professionals Involved in the Treatment and Care of COVID 19 Patients in India


• Hybrid Trial for Alcohol Reduction among People with TB and HIV in India


• Pregnancy Associated Immune Responses to Tuberculosis and HIV in India and South Africa (PARTHISA)


• Increasing Market and Public Health Outcomes Through Scaling Up Affordable Access Models of Short Course Preventive Therapy for TB (IMPAACT4TB)


• T Cell Biomarkers and T-regulatory Responses to Pediatric TB


• Inflammasome Genetics and Tuberculosis Treatment Outcomes


• Evaluation of a Urinary Biomarker Assay for Diagnosis and Test of Cure for Tuberculosis


• Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection


• Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India


• Immune Responses and Effect of Disulfiram on MTB Infected PBMCs as a Potential Host Directed Therapy


• Validating a Novel Functional Correlate of Immune Protection of Tuberculosis


• Assessing Psychological Distress among Tuberculosis Patients and Their Household Members


• Molecular Signatures of Tuberculosis-Diabetes Interaction: Transcriptomics AND METABOLOMICS Study


• The Role of Innate Immunity in the Acquisition of Sterile Protection against TB Infection


• Validation of Transcriptional Signature to Predict Active TB Disease among Advanced HIV Patients


• Biomarkers for Tuberculosis Diagnosis and Treatment Response


• Residual Respiratory Impairment Following Pulmonary Tuberculosis


• Implementing the Comprehensive Unit-based Safety Program to Reduce Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India


• Evaluating the Source of Neonatal Bloodstream Infections due to Classically Hospital Acquired Pathogens in the Neonatal Intensive Care Unit in Pune, India


• Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India


• Vaginal Microbiota in HIV Infected and Uninfected Pregnant Women (Stand Alone)


• Assessing the Feasibility and Acceptability of a Computer-based Avatar-delivered Alcohol Reduction Intervention


• Gut Microbiota of HIV Infected Pregnant Women


• Investigating Maternal Antibodies to Modify Infant Tuberculosis Acquisition


• Vaginal Microbiota in HIV Infected Pregnant Women


• Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis


• Optimizing Treatment to Improve TBM Outcomes in Children


• Markers of Lung Impairment in HIV-TB Coinfected Indian Adults


• Assessment of Depression and Anxiety among HIV-infected Adolescents in Pune, India


• Assessment of Cardiovascular Health Knowledge, Preventive Practices and Cardio-protective Behavior among HIV-infected Individuals in Pune, India


• TREAT Asia Observational Database


• Prevalence and Risk Factors for Oral Cancer among HIV-Infected Adults


• Prevalence Survey of Risk Factors for Tuberculosis and Non-communicable Diseases in an HIV-positive Population in Pune, India

Selected Publications

View all on PubMed

Gupte AN, Kumar P, Araújo-Pereira M, Kulkarni V, Paradkar M, Pradhan N, Menon P, Chandrasekaran PD, Hanna LE, Yogendra Shivakumar SVB, Rockwood N, Du Bruyn E, Karyakarte R, Gaikwad S, Bollinger R, Golub J, Gupte N, Viswanathan V, Wilkinson RJ, Mave V, Babu S, Kornfeld H, Andrade BB, Gupta A. Baseline IL-6 is a biomarker for unfavorable tuberculosis treatment outcomes: a multi-site discovery and validation study. Eur Respir J. 2021 Oct 28:2100905. doi: 10.1183/13993003.00905-2021. Epub ahead of print. PMID: 34711538.

Garibaldi BT, Fiksel J, Muschelli J, Robinson ML, Rouhizadeh M, Perin J, Schumock G, Nagy P, Gray JH, Malapati H, Ghobadi-Krueger M, Niessen TM, Kim BS, Hill PM, Ahmed MS, Dobkin ED, Blanding R, Abele J, Woods B, Harkness K, Thiemann DR, Bowring MG, Shah AB, Wang MC, Bandeen-Roche K, Rosen A, Zeger SL, Gupta A. Patient Trajectories Among Persons Hospitalized for COVID-19 : A Cohort Study. Ann Intern Med. 2021 Jan;174(1):33-41. doi: 10.7326/M20-3905. Epub 2020 Sep 22. Erratum in: Ann Intern Med. 2021 Jan;174(1):144. PMID: 32960645; PMCID: PMC7530643.

Gupta A, Montepiedra G, Aaron L, Theron G, McCarthy K, Bradford S, Chipato T, Vhembo T, Stranix-Chibanda L, Onyango-Makumbi C, Masheto GR, Violari A, Mmbaga BT, Aurpibul L, Bhosale R, Mave V, Rouzier V, Hesseling A, Shin K, Zimmer B, Costello D, Sterling TR, Chakhtoura N, Jean-Philippe P, Weinberg A. Isoniazid preventive therapy in HIV-infected pregnant and postpartum women. N Engl J Med. 2019 Oct 3;381(14):1333-1346. PMID: 31577875.

Swindells S, Ramchandani R, Gupta A, Benson CA, Leon-Cruz J, Mwelase N, Jean Juste MA, Lama JR, Valencia JV, Omoz-Oarhe A, Supparatpinyo K, Masheto G, Mohapi L, da Silva Escada RO, Mawlana S, Banda P, Severe P, Hakim J, Kanyama C, Langat D, Moran L, Andersen J, Fletcher CV, Nuermberger E, Chaisson RE for the BRIEF TB/A5279 Study Team. One month of rifapentine plus isoniazid to prevent HIV-related tuberculosis. N Engl J Med. 2019;380:1001-1011. DOI: 10.1056/NEJMoa1806808.

Mave V, Chandanwale A, Kagal A, Khadse S, Kadam D, Bharadwaj R, Dohe V, Robinson ML, Kinikar A, Joshi S, Raichur P, McIntire K, Kanade S, Sachs J, Valvi C, Balasubramanian U, Kulkarni V, Milstone AM, Marbaniang I, Zenilman J, Gupta A. High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India. J Infect Dis. 2017 Apr 15;215(8):1312-1320. doi: 10.1093/infdis/jix114. PMID: 28329303; PMCID: PMC5853545.