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Orthopaedic Research and Clinical Trials

Researchers in the lab.

The Department of Orthopaedic Surgery’s distinguished history is grounded on Johns Hopkins Medicine’s principle that laboratory research and bedside teaching need to coexist in the instruction and practice of medicine. The creation of a formal Research Division and the Center for Musculoskeletal Research in 2009 provided a nexus for basic and translational research related to the musculoskeletal system.


T32 Training Program

A NIH-sponsored T32 training program combines the training of orthopaedic residents and postdoctoral scientists through a unique structure, which requires both research and didactic phases to occur concurrently by teams of trainees.


Clinical Trials

For a complete list of available clinical trials, search the database at the Johns Hopkins Institute for Clinical and Translational Research. You can search by condition, researcher or doctor’s name.

  • Summary: A study of MACI in patients aged 10 to 17 years with symptomatic chondral or osteochondral defects of the knee (PEAK). 

    Objective: To evaluate an experimental treatment for knee cartilage defects called membrane-induced autologous chondrocyte implantation (MACI).

    Principle Investigator: R. Jay Lee, M.D.

    Eligibility Criteria: Children age 11-17 with knee cartilage defects

    Contact: Gabrielle Richard ([email protected])

    Learn more about this study.

  • Summary: A Post-Market, Prospective, Multi-Center, Open-Label, Single Arm Clinical Evaluation of the Integra TitanTM Modular Shoulder System 2.5 for Primary Shoulder Joint Replacement (IRB00169712).

    Objective: To evaluate 2-year implant survivorship in subjects who receive the TSS-2.5 when used for primary shoulder arthroplasty.

    Principle Investigator: Umasuthan Srikumaran, M.D., M.P.H., M.B.A.

    Eligibility Criteria: Candidate for total shoulder arthroplasty.

    Contact: Sanjana Vattigunta (443-516-1550 or [email protected])

    Learn more about this study.

  • Summary: A study of MACI in patients aged 10 to 17 years with symptomatic chondral or osteochondral defects of the knee (PEAK). 

    Objective: Evaluate overall pain medication consumption following surgical treatment for shoulder pathology

    Principle Investigator: Umasuthan Srikumaran, M.D., M.P.H., M.B.A.

    Eligibility Criteria: Opioid-naive adults age 18-90 years old planning to undergo surgical treatment for shoulder pathology with Dr. Uma Srikumaran.

    Contact: Sanjana Vattigunta (443-516-1550 or [email protected])

  • Objective: Improve health care for patients with chronic lower back pain (LBP) and increase the likelihood that patients obtain outcomes that matter most to them.

    Principle Investigator: Richard Skolasky, Sc.D.

    Eligibility Criteria: Adults age 18 - 64 years old, meets NIH Task Force definition of chronic LBP, had a healthcare visit for LBP in the past 90 days and have moderate levels of pain and disability.

    Contact: Tricia Kirkhart (410-502-4453 or [email protected])

    Learn more about this study.

  • Objective: To evaluate the combined effect of botulinum toxin A (administered as Dysport®) and bracing in children with adolescent idiopathic scoliosis.

    Principle Investigator: Paul D. Sponseller, M.D.

    Eligibility Criteria: Diagnosed with AIS, 10 to 16-year-old children.

    Contact: Vivian Tran and Varun Puvanesarajah (410-955-3136 or [email protected])

    Participants in this study will be compensated.

    Learn more about this study.


Featured Research Stories


Research Labs

Our orthopaedic research division and its faculty members are recognized internationally as leading innovators in musculoskeletal science and training. Our investigators conduct basic, translational and clinical research in topics that represent the great diversity of problems that impact the musculoskeletal system. Focus areas include integrative musculoskeletal biology, stem cells and regenerative medicine, skeletal neurobiology, bone metastasis and clinical outcomes.

  • Komatsu Lab

    Malfunction and malformation of blood vessels are associated with a broad range of medical conditions, including cancer, cardiovascular diseases, and neurological disorders. The ultimate goal of the Komatsu lab is to find a way to reverse the process of abnormal vessel formation and restore normal function to these vessels. In cancer, normalization of tumor blood vessels facilitates lymphocyte infiltration, potentiating anti-tumor immunity, and enhances the efficacy of immunotherapies as well as conventional cancer treatments. Normalization of regenerating blood vessels is also necessary for reestablishing blood flow to ischemic hearts and limbs, and preventing blindness caused by diabetic retinopathy or macular degeneration. Komatsu lab’s research is uncovering key molecular pathways important for the normalization of pathological vasculature.

    Principal Investigator

    Masanobu Komatsu, Ph.D.

  • Spine Outcomes Research Center

    The Spine Outcomes Research Center is a multidisciplinary group committed to improving patient outcomes and applying high-quality and purposeful research to professional practice. The organization values collegial interaction and strong scientific principles.

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