Core C: Neuropathology

The Neuropathology Core (Core C) of the Johns Hopkins Udall Parkinson’s Disease Research Center has three overarching goals. The first is to conduct postmortem neuropathological assessments in subjects from the Clinical Core and to distribute autopsy brain tissues for research to Projects 1, 2 and 4 and the Proteomic Core. The second is to obtain a comprehensive genetic profile of all the postmortem tissues available in the Udall Center collection. The third is to provide support for the morphological evaluation of genetically engineered mouse models by investigators in Projects 1, 2 and 4.

The specific aims of Core C are as follows: (1) to arrange and perform neuropathological autopsies of cases of Parkinson’s disease (PD) and Lewy body disease (LBD), and control subjects followed by the Clinical Core, and to formulate pathological diagnoses; (2) to accession, prepare, catalog, and assist in the analysis of human postmortem tissues from cases ofPD/LBD and related disorders, as well as age-matched and also younger controls for studies proposed in Projects 1, 2 and 4 and the Proteomic Core; (3) to characterize the molecular genetic profiles of PD/LBD postmortem tissues available in the BRC through a collaboration with the Laboratory of Neurogenetics at NIA (A. Singleton, Ph.D.); and (4) to use CLARITY technology for preparation of mouse brain tissues in support of studies delineated in Projects 1, 2 and 4.

Team Members

Liam Chen (Co-investigator)

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