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Tracking Myelin Producing Cells and Understanding How Inflammation Inhibits Remyelination

We are using a new animal model, developed at Johns Hopkins, in which the cells that make myelin are marked with a fluorescent protein. Once marked, or tagged, these cells can be tracked so that we can better understand how inflammation blocks remyelination and what might be done to enhance remyelination. We have found some drugs that stimulate remyelination in animals and are testing them in parallel in human cell cultures.

Presently we are testing drugs that could one day be used to repair some of the damage from MS. Collaborators include Drs. Peter Calabresi and Emily Potter.

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