Cigarette Restitution Fund at Johns Hopkins
There is no more exciting time to be a part of cancer medicine and prevention than now. We are now beginning to see the pay off from decades of dedicated work against cancer. Over the past three years, despite the growth and aging of our population, the total number of cancer deaths has declined for the first time.
Still, for far too many people, more than a million a year, cancer remains a very real threat to health, happiness, and to life itself. And, when we consider how many of us have a family member or close friend with some form of cancer, it is clear that the collection of diseases we call cancer touches everyone.
The Maryland Cigarette Restitution Fund
Dr John Groopman explains how the Maryland Cigarette Restitution Fund has transformed cancer research at the Johns Hopkins Kimmel Cancer Center and continues to be a source of new therapies and strategies to reduce the burden of cancer in Maryland.
For information on recent CRF news and events, visit the Cancer Prevention & Control website.
You can also download the CONQUEST, a publication of the Maryland Cigarette Restitution Fund and report on the CRF funds at Johns Hopkins.
The following is a sampling of CRF investigators whose research has made headlines.
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CRF researcher Joseph Califano is working to develop a test that could detect the presence of certain cancers of the head and neck based on compounds found in saliva. A simple mouth rinse could be all it takes to capture genetic signatures common to head and neck cancers.
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A growth-promoting gene called PIK3CA, linked to cancer by CRF investigator Victor Velculescu, is believed to be one of the most frequently mutated in cancer, and now we know what the enemy looks like. A research team from the Johns Hopkins University created a 3-D picture of the gene and, onto the model, mapped all cancer-associated mutations.
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Kimmel Cancer Center investigators, including CRF-funded Mary Armanios, have identified the genetic culprits that trigger a hereditary form of a fatal lung disease. The findings may provide new directions in diagnosis and treatment for families that inherit genes for the disease, as well as for those that develop noninherited forms of the illness.
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According to a new study by CRF researcher Maura Gillison, the sexually transmitted virus that causes cervical cancer in women is poised to become one of the leading causes of oral cancer in men. Gillison’s findings have attracted the attention of cancer experts worldwide.
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A 2001 CRF grant has allowed Dr. Connie Trimble to launch a clinical unit to screen women for early stages of cervical cancer; develop and test a vaccine to protect against cervical cancer in women infected with human papillomavirus (HPV); and study the reasons women are still developing cervical cancer in a time when screening is widely available.
So, while there is much we have accomplished, there is yet more we need to do. I truly believe, that with the continued support from the state and other donors, the Johns Hopkins Kimmel Cancer Center will shape the future that will ultimately see us conquer cancer.
While cancer is now recognized as a genetic disease, investigators also realize that most of the gene mutations that lead to cancer are acquired, not inherited. As a result, this provides many opportunities for prevention through behavioral and environmental modifications to derail cancer initiation. Many of the most common cancers are caused by environmental and behavioral factors that are known and potentially alterable. Among these things are HPV infection, inflammation, poor diet, and smoking.
Collaborations with our many partners throughout Maryland have allowed us to educate our citizens about cancer prevention and detection. Our goal is not only to teach people about cancer screening services, but to guide and support them as they put what they’ve learned into place.
William G. Nelson, M.D., Ph.D.
Marion I. Knott Professor and Director
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
John D. Groopman, Ph.D.
Anna M. Baetjer Professor and Chair of Environmental Health Sciences
Johns Hopkins Bloomberg School of Public Health
Research Grants
The research component of the Cigarette Restitution Fund Program (CRFP) has provided an unprecedented opportunity for Johns Hopkins, through its nationally top-ranked Sidney Kimmel Comprehensive Cancer Center, to apply our world-class research specifically to the cancer problems in the State of Maryland.
Our leadership and researchers are dedicated to using these funds to the full extent. CRF investigators speak for themselves with their increasing recruitment, effective education, screening, and treatment services, along with working collaborativley with clinicians and researchers outside of Johns Hopkins.
To date, 60 Translational Research Awards, 24 Faculty Retention Awards, and 48 Faculty Recruitment awards have been made to Hopkins investigators through the CRFP.
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- Recruit and retain faculty
- Uncover genetic causes of cancer
- Identify environmental causes of cancer
- Develop cancer vaccines
- Map sources of carcinogen exposure
- Construct core facility for collection of specimens
- Develop screening and diagnostic tests for cancer
- Address cancer problems specific to Marylanders
- Invent new cancer-related technologies—Seven investigators have received licenses or provisional patents for their inventions.
- Detect, diagnose, and treat prostate cancer
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Apply for a Grant
*Please note, these funds are only for investigators at Johns Hopkins*
Applications for funding through the Cigarette Restitution Fund research grant to Johns Hopkins are reviewed and awarded periodically. The focus should be on translational research that moves a laboratory discovery into a patient or population research setting or an observation in patients or populations into a laboratory environment. Research should be targeted toward reducing morbidity and mortality rates for breast, cervical, colon, lung, oral, melanoma, and prostate cancers in Maryland, and specifically within minority populations. Review criteria include quality and innovation of a scientific proposal and the relevance to the mission of the program established by the Cigarette Restitution Fund. Recipients will be announced in future issues of Conquest. Application procedures are as follows:
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- Title of project
- Name, address, phone and fax number, and email address of applicant
- New or renewal application for faculty recruitment or faculty retention
- Category or research: behavioral sciences, genetic epidemiology, cancer epidemiology, molecular genetics of cancer, viral vaccine development, or clinical translational research that contributes to community-focused cancer research.
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- NIH 398 Biographical Form
- Body of Grant (two pages or less)
- Goals of the faculty member related to the mission of the program
- Time commitment
- Description of translational research proposed and the likely two-year outcomes
- Description of how minority and high-risk groups will be targeted
- List of references
- Budget Request
- NIH 398 Budget Form (DD)
- Sponsor Information
- A letter of support outlining resources available to faculty member. The letter should also describe other sources of sup-port for the recruitment or the proposed work and whether this is a new recruitment or retention proposal.
Applications should be submitted online (http://public.onc.jhmi.edu/pilotprojects/) or to:
Caitlin Campbell
Executive Administrator for Cigarette Restitution Fund Grant
The Sidney Kimmel Comprehensive Cancer Center
650 Orleans Street
Room G86
Baltimore, MD 21287
Phone:(410) 955-8800
Public Heath
Community-Based Screening Programs
The Baltimore City Health Department, in its 1999 Annual Report, cited cancer as the leading cause of death among African-American males. This report, as well as the Maryland Department of Health’s Baseline Cancer Report in August 2000, confirmed that African-Americans bear a disproportionate share of the cancer burden. The disparity in prostate cancer incidence and mortality rates for Baltimore City is among the greatest nationwide. The Johns Hopkins Cigarette Restitution Fund (CRF) Public Health Grant addressed this public health problem by focusing on prostate cancer in Baltimore’s African-American and other medically underserved populations. Cancer prevention, by both education and screening, was conducted through collaborations with community-based and faith-based partners throughout Baltimore City.
Under the direction of the Baltimore City Community Health Coalition, Hopkins clinicians collaborated with colleagues at the University of Maryland, the Baltimore City Health Department, and the Maryland’s Department of Health and Mental Hygiene (DHMH) to achieve the goals of the Baltimore City Cancer Plan at Johns Hopkins (BCCP). The BCCP provided no-cost prostate cancer education, screening, diagnosis and treatment for uninsured and underinsured residents of Baltimore City. Community-based and Hopkins-based physicians performed prostate cancer screening that involved two tests: 1) a blood test that detects the prostate specific antigen or PSA, and 2) a digital rectal exam or DRE. The testing was done at various community sites and clinics (including Wald Clinic, Shepherd’s Clinic, East Baltimore Medical Center (EBMC), and Baltimore City Housing and Development). Case management and necessary follow-up care or treatment was also provided.
Hopkins broadened its program to include community education, screening, diagnosis and treatment of breast cancer through a grant from the Avon Foundation. Johns Hopkins also offered similar services for colorectal cancer, through a project grant from the Centers for Disease Control (CDC) to DHMH. Through this program, five local Hospitals, including Johns Hopkins provided no-cost colon cancer screening for uninsured and underinsured residents of Baltimore City. Currently, faculty from the Johns Hopkins gastrointestinal program collaborate with representatives from the Baltimore City Health Department through its CRF Public Health Grant to provide colonoscopy screening to uninsured Baltimore residents.
The Kimmel Cancer Center no longer receives direct CRF support for cancer screening in uninsured and minority populations, but it remains a key initiative for our Center. Johns Hopkins Priority Partners, a Medicaid MCO with more than 185,000 participants, and Johns Hopkins community physicians, who care for more than 260,000 patients, continue to meet the needs of Maryland’s underserved populations by providing screenings for colon, prostate, breast, and cervical cancers.
The Cigarette Restitution Fund: What is it?
In the late 1990’s, attorneys from nearly every state in the U.S. brought suit against America’s cigarette manufacturers. They sought reimbursement for the huge costs to states incurred due to smoking-related diseases like cancer. Months of testimony, including evidence that the manufacturers had known for many decades the deadly and addictive nature of their product, were presented. In the end, the court ruled in favor of the states, slapping the nation’s major cigarette manufacturers with $53 billion in penalties. The award, known as the Master Settlement Agreement, was split between 46 states, including Maryland, five territories, and Washington, D.C.
In 1999, Maryland’s Governor Parris N. Glendening and the General Assembly were among the first of their lawsuit counterparts to use their award establishing the multi-million dollar Cigarette Restitution Fund (CRF). State leaders have continued to allocate funds throughout our state for smoking-cessation programs and education, crop conversion assistance for tobacco farmers, cancer research, prevention, education, screening, and treatment, and other smoking and cancer-related initiatives.
A major component of the CRF was the creation of the Statewide Academic Health Center grant, through which cancer research funds for the University of Maryland and Johns Hopkins were appropriated. Grant funds under this initiative support translational research and are aimed at reducing morbidity and mortality due to the seven targeted cancers- breast, cervical, colon, lung, melanoma, oral and prostate- in Maryland.
Maryland cigarette restitution fund research grant awardeesGrant Award Winners
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Kassandra Alcaraz, Ph.D., M.P.H. and Frank Curriero, Ph.D.: Understanding and AddressingAdverse Social Determinants of Health to Reduce Cancer-related Disparities in Maryland Communities FACULTY RETENTION, NEW
Rebkha Atnafou, M.A.: Identifying Barriers and Promoters to Colorectal Cancer Screening for Black Immigrants and Refugees in the Metropolitan Baltimore and Prince George’s County: A Qualitative Study TRANSLATIONAL RESEARCH, NEW
Jeanne Clark, M.D., M.P.H. and Heidi Hutton, Ph.D.: Feasibility and RCT Pilot of an Avatar-Delivered Computerized Intervention for Tobacco Cessation with Community Health Worker Linkage to Lung Cancer Screening In Baltimore City TRANSLATIONAL RESEARCH, CONTINUATION
Jenell S. Coleman, M.D., M.P.H.: Identifying Determinants of Postpartum HPV Vaccination Uptake: A Qualitative and Quantitative Approach FACULTY RECRUITMENT, NEW
Avonne Connor, Ph.D., M.P.H.: Disparities in the Association between Obesity and Cancer-RelatedPainAmongFemaleCancerSurvivorsinMarylandTRANSLATIONALRESEARCH,NEW
Dulce Cruz-Oliver, M.D.: Enhancing Self-Efficacy and Lowering Anxiety Through a Telenovela Intervention for Caregivers of African American and Hispanic Hospice Cancer Patients: Pilot Trial TRANSLATIONAL RESEARCH, NEW
MichaelDejardins,Ph.D.:SpatialScience Approachesto EvaluatePatientUtilizationof SKCCC’s
Clinical Trialsbefore and during the COVID-19 EraTRANSLATIONAL RESEARCH, NEW
Atul Deshpande, Ph.D., M.S.: A Machine Learning Framework for Delineating Spatial Cell-Cell Interactions Predictive of Cabozantinib/Nivolumab Therapy Response in Real and Virtual Hepatocellular Carcinoma Tumors FACULTY RECRUITMENT, CONTINUATION
Roy Elias, M.D.: DisentanglingAncestry-InfluencedGene Expressionin Prostate Cancer Usinga Multi-Omic Deep Exploratory Non-Negative Matrix Factorization Framework TRANSLATIONAL RESEARCH, NEW
Panagis Galiatsatos, M.D.: Tobacco Free Community: Expanding Efforts for Smoking Cessation and Lung Cancer Screenings in Populations With Psychiatric and Mental Health Co-Morbidities TRANSLATIONAL RESEARCH, CONTINUATION
Joel Gittelsohn, Ph.D.: Developing an Agent-Based Model to Inform Programs and Policies Aimed at Improving Healthy Food Access and Reducing Cancer Risk In Baltimore City TRANSLATIONAL RESEARCH, CONTINUATION
John Groopman, Ph.D.: Global Discovery and Profiling Changes of Human Albumin Modifications by Pan-Protein Adductomics: Initial Application to Inflammation Derived Adducts Related to Bariatric Surgery TRANSLATIONAL RESEARCH, CONTINUATION
Peng Huang,Ph.D.and HariEaswaren,Ph.D.:AI-guided Indeterminate PulmonaryNodules Clinical Decision System TRANSLATIONAL RESEARCH, NEW
Jacky Jennings, Ph.D.: PRO BEAD Shared Resources TRANSLATIONAL RESEARCH, CONTINUATION
Burles Johnson, III, M.D.: Identification of Tumor Targets Using Optimized Preclinical Bladder Cancer Models FACULTY RETENTION, NEW
Miranda R. Jones, Ph.D.: Unraveling Connections: Social Determinants of Health and Their ImpactonSmoking Behaviors among Adults withand withoutaHistoryof Cancer TRANSLATIONAL RESEARCH, NEW
Alison Klein, Ph.D. and Zachariah Foda, M.D.: Pilot Study of Targeted Community-Based Colorectal Cancer Screening Tailored to Low-Uptake Communities in Baltimore City and Western Maryland TRANSLATIONAL RESEARCH, NEW
Kirsten Koehler, Ph.D., Lesliam Quiros-Alcala, Ph.D., M.Sc., Ana Rule, Ph.D.: Environmental Exposuresand CancerMortalityAmong Maryland AdultsTRANSLATIONALRESEARCH, CONTINUATION
Leila J. Mady, Ph.D., M.P.H.: Understanding Demographic and Social Determinants of Health on Tobacco Dependence and Financial Toxicity in Lung and Head and Neck Cancers FACULTY RECRUITMENT, CONTINUATION
Hailey Miller, Ph.D., R.N.: A Community-Driven, Nurse-Led Dietary Intervention For Adults With Overweight or Obesity TRANSLATIONAL RESEARCH, NEW
Aliyah Pabani, M.D., M.P.H.: Improving Access for Expert Management of Immunotherapy-Related Adverse Events FACULTY RECRUITMENT, NEW
Chintan Pandya, Ph.D., M.P.H., M.B.B.S.: Examining Disparities in Access and Outcomes of Immune-Based Cancer Treatments: A Comparative Analysis of Patients Covered by Medicaid vs. Private Insurance Using Johns Hopkins Electronic Health Records and Claims Data TRANSLATIONAL RESEARCH, NEW
Jenni Yeong-Shin Sheng, M.D.: Gut microbiome, Adverse effects, and Markers through Metabolic Reprogramming (GAMMER) StudyFACULTY RETENTION, NEW
Dimitri N. Sidropoulos, Ph.D.:Tracking Lymphocyte Dynamics Across Tumors, Lymph Nodes and Periphery To Optimize Cancer Vaccine Strategies FACULTY RECRUITMENT, NEW
Kala Visvanathan, M.D, M.H.S.: Improving Breast Cancer Disparities in Maryland by Addressing Breastfeeding Adults TRANSLATIONAL RESEARCH, CONTINUATION
Govind Warrier, M.D., M.P.H.: Innovating Inclusion: Implemen ting a Digital Patient Navigation Platform to Improve Access to Expert Melanoma Care and Clinical TrialsFACULTY RECRUITMENT, NEW
H. Catherine Wilbur, M.D.: Characterization of the molecular landscape of sarcoma to inform cancer risk and treatment FACULTY RECRUITMENT, NEW
Jessica Yeh, Ph.D.: Scaling up Behavioral Weight Loss Opportunities for Cancer Survivors inMaryland with Overweight or ObesityTRANSLATIONAL RESEARCH, CONTINUATION