The Vascular Biology program studies the development of new blood vessels, working to uncover where stem cells go and what they do once transplanted into the body. Specific projects are looking to engineer cells and scaffolding biomaterials to make cell therapies detectable in the body after transplant using MRI, ultrasound or other imaging tools for conditions like diabetes, cancer and stroke. Additional studies are investigating the role of hypoxia-inducible factors (HIFs)—proteins that regulate oxygen consumption—in the maintenance of cancer stem cells within breast tumors and the ability of cancer cells to evade the immune system. Scientists are also trying to develop proteins to inhibit HIF for the treatment of cancers and blinding eye diseases.
The Vascular Biology Program at Johns Hopkins' Institute for Cell Engineering
Researcher Gregg Semenza introduces the Vascular Biology Program, where scientists trace cells as they move through the body and study the relationship between low-oxygen conditions, blood vessel growth, and cancer.