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The Immunobiology Program

Researchers in the Immunobiology program are working to unravel the molecular mechanisms of the human immune system. In a range of projects, scientists are exploring the role of the microbiome in anti-cancer immune responses, working to understand the circuitry in immune cells that allows them to sense pathogens and cancerous cells to mount a response without harming the host, and trying to uncover how a dysregulation of signaling in immune cells can convert the cells into cancers like lymphoma, for example.

Some current research projects are:

  • Studying how target cells are recognized and eliminated by the immune system 
  • Investigating a novel mechanism that exposes cryptic information that can be recognized by the immune system
  • Studying a novel immune surveillance mechanism involved in obesity
  • Analyzing the underlying mechanisms of how the immune system recognizes native versus foreign tissue
  • Exploring the role of the microbiome in anti-cancer immune responses 
  • Using a nanoparticle-based approach to try to change the tumor immunosuppressive microenvironment into one where immune system T cells can eliminate cancers
  • Employing an artificial intelligence-inspired algorithm to study T cell diversity, learning how T cells respond to stresses like infections or cancer
  • Studying how Johns Hopkins-designed artificial antigen presenting cells can help stimulate immune responses
  • Working to understand the circuitry in immune cells that allows them to sense pathogens and cancerous cells to mount a response without harming the host
  • Trying to uncover how a dysregulation of signaling in immune cells can convert the cells into cancers like lymphoma, for example
  • Seeking to understand the molecular basis for immunodeficiency associated with the signaling protein CARD11
  • Working to understand the circuitry in immune cells that allows them to sense pathogens and cancerous cells to mount an immune response

 

The Immunobiology Program at Johns Hopkins’ Institute for Cell Engineering

Stephen Desiderio introduces the Immunobiology Program, where scientists study how our immune system works and look for ways to bolster it.

Faculty

Photo of Dr. Joel L. Pomerantz, Ph.D.

Pomerantz, Joel L., Ph.D.

Associate Professor of Biological Chemistry
Associate Professor of Oncology
 
Photo of Dr. Jonathan Schneck, M.D., Ph.D.

Schneck, Jonathan, M.D., Ph.D.

Professor of Pathology
Professor of Oncology
 
Photo of Dr. Nilabh Shastri, M.Sc., Ph.D.

Shastri, Nilabh, M.Sc., Ph.D.

Professor of Pathology