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Richard W. TeLinde Gynecologic Pathology Research Program

The study of how uterine cancer cells become metastatic through functional genomic and metabolomic analyses. An artist's rendition of studying how uterine cancer cells become metastatic through functional genomic and metabolomic analyses.

The Richard W. TeLinde Gynecologic Pathology Research Program continues the tradition of its namesake by advancing science in studying gynecologic diseases, and training scientists and physicians as future leaders in their fields. Dr. Richard W. TeLinde, a former director of the Department of Gynecology at Johns Hopkins, was an accomplished physician, visionary researcher and dedicated educator. With his generosity, this interdepartmental program was established in 1988 and is currently directed by Ie-Ming Shih, M.D., Ph.D., who continues his legacy and fulfills his vision in gynecologic pathology research.

The program's research activities are reflected in the making of new scientific discoveries in gynecologic pathology and receiving several program grant awards from the National Institutes of Health's Cervical Cancer SPORE, the Department of Defense Ovarian Cancer Consortium and the NIH/NCI UO1 Early Detection Network study, in addition to individual research awards. This program has supported the Johns Hopkins Gynecologic Tumor Bank for more than a decade.

Our strong commitment to continuing the legacy of Dr. TeLinde is evident in our basic science and translational research, which focuses on ovarian, uterine, and cervical cancers, as well as gestational trophoblastic diseases (tumors arising in the placental cells during the early stages of pregnancy) and endometriosis.

Gynecologic Pathology Laboratory


Research Topics

studying drug resistance in ovarian cancersThe study of drug resistance in ovarian cancer (artist's rendition).

Ovarian Cancer

Ovarian cancer is one of the most aggressive gynecologic cancers and remains one of the least understood. Our scientists are developing new tools to identify and characterize molecular alterations that occur during the formation and progression of ovarian cancers. Recent genome-wide analyses by Johns Hopkins investigators have pinpointed specific molecular changes in several new cancer-associated genes, including ARID1A, Rsf-1, SYK, NAC-1 and Notch3. Our translational research focuses on early cancer detection using body fluid samples ("liquid biopsy") and innovative molecular techniques. We are also studying new therapeutic reagents and immunotherapies that target cancer-associated molecules, with the goal of developing new drugs to treat recurrent ovarian cancer. 

Dr Shih and Dr Wang analyzing medical image

Johns Hopkins Awarded Ovarian Cancer SPORE Grant


The expert research teams at Johns Hopkins Medicine and the University of Pennsylvania — joint recipients of this prestigious Specialized Program of Research Excellence (SPORE) grant — will work collaboratively to utilize recent laboratory research discoveries to develop new methods for early ovarian cancer detection and treatment.

Learn more about our Ovarian SPORE research and clinical trials.

Uterine Cancer

Uterine corpus cancer is the most common gynecologic cancer and its incidence is rising. In order to better understand how it develops and progresses, the investigators at Johns Hopkins are studying its causes at the molecular level. Our researchers are also developing new molecular methods that can be introduced to clinics for screening uterine cancer using cervical cytology specimens (like the Pap smear). Our clinical scientists are evaluating new therapeutic strategies to benefit patients who suffer from specific types of uterine cancer in a clinical trial setting.

Cervical Cancer

Johns Hopkins is a member of the Specialized Program of Research Excellence in Cervical Cancer. With support from the National Cancer Institute, we are conducting basic, translational and clinical studies to prevent and treat cervical cancers. Previous studies have identified connections between immune system genes and HPV16. Current projects include the development of next-generation HPV vaccines to control HPV-associated precursor lesions and invasive cancer. Our dedicated researchers are working to extend the techniques used in HPV vaccine development to the creation of vaccines targeting other cancers with defined tumor antigens.

Studying the pathogenesis of endometriosisThe TeLinde Laboratory works with the Howard W. and Georgeanna Seegar Jones Laboratory of Reproductive Sciences and Women's Health Research to study the pathogenesis of endometriosis (artist's rendition).

Endometriosis

The faculty members in this program closely collaborate with researchers in the Howard W. and Georgeanna Seegar Jones Laboratory of Reproductive Sciences and Women's Health Research to study the molecular pathogenesis and translational aspects of endometriosis, a disease that affects many women of childbearing age.

The team has applied next-generation sequencing and other state-of-the-art technologies to explore the origin, clonal evolution and mechanisms of the “metastatic” nature of endometriosis. Moreover, we are assessing new biomarkers and developing new methods for early detection and risk prediction of endometriosis. Investigators are also studying the molecular mechanisms behind how some endometriosis cases develop into endometriosis-related ovarian cancers.

Gestational Trophoblastic Disease

Gestational trophoblastic disease includes a heterogeneous group of tumors and tumor-like lesions with specific clinical features, morphologic characteristics and pathogenesis. The investigators in our program have an interest in studying their pathogenesis by demonstrating molecular alterations that are associated with the development of various types of trophoblastic tumors. Since a correct diagnosis of different types of trophoblastic disease is critical for clinical management, the gynecologic pathologists in this program have applied both morphology-based and molecular tests to precisely diagnose these lesions.


Program Director

Photo of Dr. Ie-Ming Shih, M.D., Ph.D.

Shih, Ie-Ming, M.D., Ph.D.

Professor of Gynecology and Obstetrics
Professor of Oncology
Professor of Pathology
Richard W. TeLinde Distinguished Professor, Department of Gynecology and Obstetrics
Director of TeLinde Gynecologic Pathology Laboratory
Co-Director, Breast and Ovarian Cancer Program, Sidney Kimmel Comprehensive Cancer Center
Expertise, Disease and Conditions: Endometriosis, Gynecologic/Obstetric Pathology, Pathology
 

Researchers

Photo of Dr. Stephanie Louise Gaillard, M.D., Ph.D.

Gaillard, Stephanie Louise, M.D., Ph.D.

Assistant Professor of Oncology
Assistant Professor of Gynecology and Obstetrics
Expertise, Disease and Conditions: Cervical Cancer, Chemotherapy, Endometrial Cancer, Immunotherapy, Ovarian Cancer, Targeted/Biologic Therapy
 
Photo of Dr. Chien-Fu Hung, Ph.D.

Hung, Chien-Fu, Ph.D.

Associate Professor of Pathology
Associate Professor of Gynecology and Obstetrics
Associate Professor of Oncology
Research Interests: Gene therapies, cancer vaccines, ovarian cancer immunotherapy, cancer immunology
 
Photo of Dr. Kimberly Lynn Levinson, M.D., M.P.H.

Levinson, Kimberly Lynn, M.D., M.P.H.

Assistant Professor of Gynecology and Obstetrics
Associate Director of Gynecologic Oncology, Greater Baltimore Medical Center
Assistant Program Director, GYN/OB Residency Program, Greater Baltimore Medical Center
 
Photo of Dr. Tricia Ann Murdock, M.D.

Murdock, Tricia Ann, M.D.

Assistant Professor of Pathology
Expertise, Disease and Conditions: Gynecologic/Obstetric Pathology, Pathology
 
Photo of Dr. Richard B. S. Roden, Ph.D.

Roden, Richard B. S., Ph.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Professor of Oncology
Co-Director, Cancer Prevention and Control Program, Sidney Kimmel Comprehensive Cancer Center
Research Interests: Human papillomavirus (HPV), ovarian cancer, HPV virology, HPV preventive vaccine, ovarian cancer pathogenesis, proteosome inhibitor, experimental therapeutics
 
Photo of Dr. Brigitte Maria Ronnett, M.D.

Ronnett, Brigitte Maria, M.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Expertise, Disease and Conditions: Pathology
Research Interests: Gynecologic pathology, molecular diagnosis of molar pregnancy, pathology of mucinous ovarian neoplasm, clinicopathological characterization of gynecologic neoplasms
 
Photo of Dr. Russell Stephen Vang, M.D.

Vang, Russell Stephen, M.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Director, Division of Gynecologic Pathology In-house Service
Co-Director, Gynecologic Pathology Fellowship Training Program
Co-Director, Gynecologic Pathology Consultation Service
Expertise, Disease and Conditions: Gynecologic/Obstetric Pathology
Research Interests: Primary and secondary epithelial tumors of the ovary and fallopian tube, diagnostic gynecologic pathology, serous borderline tumor
 
Photo of Dr. Tian-Li Wang, Ph.D.

Wang, Tian-Li, Ph.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Professor of Oncology
Director of the Molecular Genetics Laboratory of Female Reproductive Cancer
Research Interests: Cancer genetics, epigenomics, chemoresistance in ovarian cancer, early detection of cancer, notch signaling, female reproductive cancer, chromatin remodeling and DNA damage repair
 
Photo of Dr. Tzyy-Choou Wu, M.D., M.P.H., Ph.D.

Wu, Tzyy-Choou, M.D., M.P.H., Ph.D.

Professor of Pathology
Professor of Gynecology and Obstetrics
Professor of Oncology
Director, Gynecologic Pathology Division
Director, Cervical Cancer Research Lab
Expertise, Disease and Conditions: Cervical Cancer, Head and Neck Cancers, Pathology
Research Interests: CD8+ T lymphocytes, cervical cancer, vaccination, human papillomavirus (HPV), HPV vaccine, cellular pathology, molecular pathology, T cell biology, tumor immunology, HPV immunology
 

Learn More About Our Research

Studying drug resistance in ovarian cancers.

Discover the unique and groundbreaking research performed at the TeLinde Laboratory, including the study of drug resistance in ovarian cancer.
Researchers determine the mechanisms that lead to uterine cancer cells becoming aggressive.

Researchers determine the mechanisms that lead to uterine cancer cells becoming aggressive.
Our research focuses on studying how uterine cancer cells become metastatic through functional genomic and metabolomic analyses.

Our research focuses on studying how uterine cancer cells become metastatic through functional genomic and metabolomic analyses.
Scientists elucidate the pathogenesis of an ovarian serous borderline tumor.

Scientists elucidate the pathogenesis of an ovarian serous borderline tumor.
Researchers study the origin of ovarian cancer.

Researchers study the origin of ovarian cancer.
This chart depicts gene expression signatures as a predictive biomarker in gynecologic neoplasms.

This chart depicts gene expression signatures as a predictive biomarker in gynecologic neoplasms.
A depiction of the anatomical locations of gynecologic cancers.

A depiction of the anatomical locations of gynecologic cancers.
Scientists in the Richard W. TeLinde Gynecologic Pathology Research Laboratory take a multidisciplinary approach to their study of gynecologic cancers.

Scientists in the Richard W. TeLinde Gynecologic Pathology Research Laboratory take a multidisciplinary approach to their study of gynecologic cancers.
Researchers study immunogenomics in gynecologic cancers.

Researcher study immunogenomics in gynecologic cancers.
Studying the pathogenesis of endometriosis.

The TeLinde Laboratory has been working with the Howard W. and Georgeanna Seegar Jones Laboratory of Reproductive Sciences and Women's Health Research to study the pathogenesis of endometriosis.
SYK kinase is targeted to sensitize paclitaxel effects.

SYK kinase is targeted to sensitize paclitaxel effects.
The role of chromatin remodeling is explored with regards to gynecologic tumors.

The role of chromatin remodeling is explored with regards to gynecologic tumors.
A complete exome sequencing analysis is performed on gynecologic cancer at different biological contexts.

A complete exome sequencing analysis is performed on gynecologic cancer at different biological contexts.
The molecular landscape of uterine serous carcinoma is explored.

The molecular landscape of uterine serous carcinoma is explored.