The Singh lab does clinical and translational research on pancreatic islet isolation and transplantation as well as acute and chronic pancreatitis.

The Tse Lab does basic and translational research on the function and regulation of sodium/hydrogen exchange-2 isoform, and molecular biology of nucleoside transporters.

Dr. Rabb’s lab is involved in translational research aimed at understanding the molecular pathogenesis of kidney ischemia/reperfusion injury. The lab is interested in the development of novel treatments for kidney IRI.

The goal of the Early Detection of Pancreatic Cancer Laboratory is to identify molecular abnormalities that can improve the outcome of patients with pancreatic cancer and those at risk of developing this disease. Much of our work is focused on translational research evaluating markers and marker technologies that can help screen patients with an increased risk of developing pancreatic cancer. Ongoing translational research programs include the Cancer of the Pancreas Screening-5, or “CAPS5” multicenter study which is supported by a U01 and R01 grant from the National Cancer Institute and a  Stand Up to Cancer Award aimed at pancreatic cancer early detection. 

The Yu Lab does basic and translational research on sensory physiology and disorders of the gastrointestinal tract. Recently funded work by the NIH/NIDDK includes specific research into the pathophysiology of how mast cells and bile salt reflux effect motility of the esophagus.

The Singh Lab does basic and translational research on intestinal ion transport, cellular physiology, and membrane trafficking in diabetic disorders and cystic fibrosis. Her work is currently focused on characterizing the role of early endosomal-PX domain binding protein Sorting Nexin-17 in intestinal fluid homeostasis and epithelial cell physiology.

Work in the Christopher Chute Lab involves the management of clinical data to enable effective evidence-based clinical practice and translational research. Recently, we developed an EHR-based genetic testing knowledge base to be integrated into the genetic testing ontology (GTO) and identified potential barriers to pharmacogenomics clinical decision support (CDS) implementation.

Investigators in the Yukari Manabe Lab evaluate the accuracy of rapid, point-of-care diagnostics for HIV, tuberculosis and related infectious diseases in resource-limited settings particularly sub-Saharan Africa and examine the impact of diagnostic interventions on disease detection and patient outcomes. The team also conducts operational and translational research in tuberculosis and HIV co-infection.

The Melia lab performs basic, translational, and clinical research on inflammatory bowel disease. Specifically, Dr Melia's basic science and translational research program is concentrated on novel roles of manganese (Mn) homeostasis in Crohn's disease and the interaction with aberrant N-glycosylation with current support from NIDDK and NICHD, including support as a co-investigator in the Center for Metals in Nutrition and Development.

Andreia Faria's Laboratory focuses on investigating brain functions using MRIs. We develop and apply methods for processing and analyzing diverse MRI modalities in order to characterize distinctive brain patterns and to study multiple conditions, including neurodegenerative diseases, psychiatric disorders, and stroke. We use artificial intelligence to develop tools for brain MRI segmentation and quantification, promoting the means to perform reliable and reproducible translational research.