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Canine Brain Cancer Clinical Trial

Study Title: Endovascular Radiosurgery in Dogs with Brain Tumors (Meningioma)
Current Status: Open and enrolling
Principle Investigators: Rebecca A. Krimins, D.V.M., M.S.rkrimin1@jhmi.eduDara L. Kraitchman, V.M.D., Ph.D.,

Summary: To assess the effectiveness of Y-90 endovascular radiosurgery in slowing or reversing the progression of canine brain tumors. Y-90 endovascular radiosurgery is a minimally-invasive, targeted injection of Yttrium-90-loaded microspheres into the blood vessels of a tumor under X-ray guidance.

Funding and Support: The diagnostic MRI scan, Y-90 endovascular radiosurgery, and PET/CT scan for the study will be fully funded. Any medications our veterinarians prescribe to alleviate the side effects of the procedure, as well as follow-up MRI imaging and blood tests will also be covered by the study.

Trial Eligibility: Dogs of any breed and sex are eligible for the study.

Inclusion Criteria:

  • The dog’s owner has the ability to understand and sign a written informed consent and is willing to comply with study protocol.
  • Extra-axial brain tumor (meningioma) >1cm in size on MRI, restricted to one side of the brain.
  • Age of at least 1 year and body weight greater than 10 lbs.
  • Other restrictions may apply. Please call for details.

Exclusion Criteria:

  • Anticipated life expectancy of less than 1 month.
  • Previous or current oncological treatment of the brain tumor.
  • Participation in another study.
  • Evidence of serious systemic disorder or other condition that is clinically incompatible with the study.

Trial Timeline:

Eligible dogs will receive an MRI scan to identify the tumor type and location. If imaging suggests that the tumor might respond well to Y-90 endovascular radiosurgery, we will perform the procedure, followed by a PET/CT scan. To assess the dog’s response to treatment, blood tests and follow-up MRI scans will be performed free of charge. Further monitoring will be performed as deemed necessary by CIGAT veterinarians.

Contact Us

To find out more about this clinical trial, send an email to or call 410-502-7325.

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