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Neurology and Neurosurgery

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Clinical Trials

Clinical trials are an important form of clinical research. We advise patients to learn about available clinical trials as soon as possible after a diagnosis is made. This allows patients to consider the most options available while working with physicians to plan treatment.

Interested in participating in a clinical trial at Johns Hopkins? SEARCH The Johns Hopkins Institute for Clinical and Translational Research (ICTR) by entering a particular condition i.e. "AIDS," "Neurology," etc. or simply enter "healthy volunteer."

For general research volunteer information, please contact us at 410-955-1853.

Experimental Drug Studies

Intranasal Insulin Therapy for HIV-associated Neurocognitive Disorders

Purpose: The future treatment for HAND will likely need to include both antiretroviral therapy and adjunctive therapy to treat central nervous system (CNS) specific pathogenetic mechanisms. Insulin is involved in multiple CNS functions including food intake, metabolism, learning, and memory. Insulin has neuroprotective properties demonstrated in cell culture experiments and in vivo models, which provide strong evidence for its use as a therapeutic agent to treat HAND. The brain delivery of insulin administered via a novel nasal drug delivery device has been shown to have CNS protective, restorative, and cognitive enhancing effects in over 15 independent clinical studies. In addition to standard neuropsychological testing, the proposed clinical trial will use several novel brain imaging and CSF surrogate markers to monitor the effects of intranasal insulin therapy in HAND patients.  We will conduct a 24 week double-blinded, placebo-controlled Phase I/II trial of intranasal insulin for the treatment of HAND. Participants will be randomly assigned to one of two groups: 1) Intranasal insulin, or 2) placebo administered with a nasal drug delivery device.  Outcomes from these studies could have important implications for the design and implementation of future insulin modifying therapies and other neuroprotective compounds for HAND.

Currently enrolling participants; if interested contact: 443-799-7241

Observational Studies (No Experimental Drug) 

HIV-related Neuroplasticity and Attention-to-Reward as Predictors of Real World Function

Purpose: The aim of this research is to identify factors that motivate a person to engage in risky behaviors that can lead to the acquisition or transmission of HIV. The relevance of this research to public health is that results have the potential to inform treatment strategies for reducing HIV transmission in at-risk populations.

Currently enrolling participants; if interested contact Cherie Marvel at (410) 502-4664.

Identifying the Neurocognitive Determinants of HIV Risk Behavior

Rewarding stimuli command one's attention. The ability to ignore a learned reward is critical to behavioral control over impulsive, risky decisions. This line of research uses brain imaging to examine what parts of the brain are affected by attentional bias for learned reward in two populations that tend to engage in risky behaviors: HIV positive individuals, and those with opioid dependence.

Currently enrolling participants; if interested contact Cherie Marvel at (410) 502-4664.

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Maryland Patients

To learn more about the Johns Hopkins NIMH Center, please call 443-287-0571.
Contact Us

Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259
Adult Neurosurgery: 410-955-6406
Pediatric Neurosurgery: 410-955-7337


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