-
About
- Health
-
Patient Care
I Want To...
-
Research
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
-
School of Medicine
I Want to...
Amyloid Neuropathy
Disorders of peripheral nerves are the most common neurological complications of systemic amyloidosis; an illness where a protein called amyloid is deposited in tissues and organs. Amyloidosis can affect peripheral sensory, motor or autonomic nerves and deposition of amyloid lead to degeneration and dysfunction in these nerves.
Symptoms
The typical symptoms of amyloid neuropathy are due to sensory and autonomic dysfunction. Patients may experience painful paresthesias (unusual sensations), numbness and balance difficulties due to sensory dysfunction and persistent nausea, vomiting, diarrhea, constipation, incontinence, sweating abnormalities or sexual dysfunction due to autonomic nerve involvement.
Diagnosis
Diagnosis of amyloid neuropathies is based on history, clinical examination and supporting laboratory investigations. These include electromyography with nerve conduction studies, skin biopsies to evaluate cutaneous nerve innervation, and nerve and muscle biopsies for histopathological evaluation. In cases of familial amyloidosis, genetic testing in the blood may be useful.
Treatment
Treatment of amyloid neuropathies is directed at both preventing further deposition of amyloid in peripheral nerves and treating painful symptoms. Depending on the type of amyloid protein, patients may benefit from liver or bone marrow transplant. Neuropathic pain due to amyloid neuropathy can be treated with anti-seizure medications, antidepressants, or analgesics including opiate drugs. In severe painful conditions patients may be referred to the Blaustein Chronic Pain Clinic for a multidisciplinary approach to pain management.
Request an Appointment
Maryland Patients
Thank you for your interest in the Johns Hopkins Peripheral Nerve Center.
Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259
Already a Patient?
Traveling for Care?
Whether you're crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.
Outside of Maryland (toll free)
410-464-6713
Request an Appointment
Medical Concierge Services
International Patients
+1-410-502-7683
Request an Appointment
Medical Concierge Services
