Skip Navigation

Phone Service Update

We are experiencing extremely high call volume related to COVID-19 vaccine interest. Please understand that our phone lines must be clear for people with urgent and acute medical care needs. Unfortunately, this means we are unable to accept phone calls to schedule COVID-19 vaccinations at this time. When this changes, we will update this web site. Read more COVID-19 Vaccine Information

Patient Care Options | Visitor Guidelines | Coronavirus Information | Self-Checker | Get Email Alerts

Search Menu
Neurology and Neurosurgery

In This Section      

Clinical Trials

A clinical trial is a method for medical researchers to study, test and discover effective treatments. Clinical trial research studies can occur in a lab or involve human beings.

For more information visit The Johns Hopkins Institution for Clinical and Translative Research (ICTR)

Study Title: OPTIMIST: Optimal Post Tpa-IV Monitoring in Ischemic Stroke

PI: Victor Urrutia, MD

Summary: To show safety of post-tPA monitoring in a non-ICU setting for patients presenting with minor stroke symptoms (NIHSS<10)

Human Study

Recruiting Status: Enrolling

Major inclusion criteria:

  • Patients receiving IV tPA for presumed stroke within 4.5 hours of symptom onset
  • NIHSS <10 at presentation and at the end of tPA infusion
  • Age 18-80 years
  • Patients do not have ICU needs by the end of the tPA infusion

Major exclusion criteria:

  • Age <17 or >80
  • ICU need or indication by the end of the tPA infusion
  • NIHSS >9 at presentation or at the end of the tPA infusion
At the end of the one-hour tPA infusion, eligible patients will be consented for this study and will continue with neurocheck and vital signs Q 15 minutes x 4 in the ED. The patient may transfer to the BRU after the third Q 15 minute interval, so that they receive the 4th in the BRU. After arrival to the BRU, they will receive a set of vital signs and neurochecks upon arrival and at one hour, then Q 2 hours for 8 hours and then Q 4 hours until completing the 24 hour post tPA.

Study Title: SMARTS: Study of Motor Learning and Acute Recovery Time Course in Stroke

PI: John Krakauer, MD

Summary: This pilot study is to evaluate and quantify the biologic factors that are associated with the natural history of recovery over stroke, and to investigate the relationship between motor learning capacity and functional recovery over the course of 12 months post stroke. Funded by the James S. McDonnell Foundation.

Recruiting Status: Enrolling

Major inclusion criteria:

  • First ever clinical ischemic stroke which qualifies per MRI evaluation
  • Residual upper extremity weakness
  • Ability to provide informed consent

Major exclusion criteria

  • Too mild upper extremity impairment
  • Age <21
  • Receptive aphasia, global inattention
  • Inability to give informed consent
  • Other co-morbid conditions, or illnesses

A clinical study is an observational study on human subjects, but unlike clinical trials is strictly for research and not interventional. Please check back for information on our current studies.

Request an Appointment

Maryland Patients

To request an appointment or refer a patient, please call:
Neurology: 410-955-2228
Neurosurgery: 410-614-1533

Request an Appointment

Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259
Adult Neurosurgery: 410-955-6406
Pediatric Neurosurgery: 410-955-7337


Traveling for Care?

Whether you're crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

Outside of Maryland (toll free)

Request an Appointment
Medical Concierge Services

International Patients

Request an Appointment
Medical Concierge Services

blue suitcase