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Clinical Trials

A clinical trial is a method for medical researchers to study, test and discover effective treatments. Clinical trial research studies can occur in a lab or involve human beings.

For more information visit The Johns Hopkins Institution for Clinical and Translative Research (ICTR)

The SQUID Trial for the Embolization of the Middle Meningeal Artery (STEM) for Treatment of Chronic Subdural Hematoma (IRB00253687)

Principle Investigator: Justin Caplan, M.D.
Contact: Whitney Isennock (, 667-306-8145)
Summary: To test the safety and efficacy (how well it works) of embolization to treat MMA bleeds using SQUID™ in surgically treated and non-surgically treated patients with cSDH.
Eligibility Criteria: People who have been diagnosed with chronic bleeding between the hard-cerebral membrane and the brain, also known as chronic subdural hematoma (“cSDH”) may join this study.
More information on NCT04410146

OPTIMIST: Optimal Post Tpa-IV Monitoring in Ischemic Stroke

Principle Investigator: Victor Urrutia, M.D.
Summary: To show safety of post-tPA monitoring in a non-ICU setting for patients presenting with minor stroke symptoms (NIHSS<10)
Major inclusion criteria:

  • Patients receiving IV tPA for presumed stroke within 4.5 hours of symptom onset
  • NIHSS <10 at presentation and at the end of tPA infusion
  • Age 18-80 years
  • Patients do not have ICU needs by the end of the tPA infusion

Major exclusion criteria:

  • Age <17 or >80
  • ICU need or indication by the end of the tPA infusion
  • NIHSS >9 at presentation or at the end of the tPA infusion

At the end of the one-hour tPA infusion, eligible patients will be consented for this study and will continue with neurocheck and vital signs Q 15 minutes x 4 in the ED. The patient may transfer to the BRU after the third Q 15 minute interval, so that they receive the 4th in the BRU. After arrival to the BRU, they will receive a set of vital signs and neurochecks upon arrival and at one hour, then Q 2 hours for 8 hours and then Q 4 hours until completing the 24 hour post tPA.

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