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Neurology and Neurosurgery

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Clinical Trials

A clinical trial is a method for medical researchers to study, test and discover effective treatments. Clinical trial research studies can occur in a lab or involve human beings.

For more information visit The Johns Hopkins Institution for Clinical and Translative Research (ICTR)

ENRICH (Early MiNimally-invasive Removal of ICH)

Contact: Whitney Isennock (410-955-7008)
Principle Investigator: Gary Gallia, M.D.
Summary: To see how well patients with intracerebral hemorrhage (ICH) recover after surgical removal of a blood clot in the brain.
Eligibility criteria: Individuals with ICH presenting to Johns Hopkins within 24 hours of ICH symptoms

OPTIMIST: Optimal Post Tpa-IV Monitoring in Ischemic Stroke

Principle Investigator: Victor Urrutia, M.D.
Summary: To show safety of post-tPA monitoring in a non-ICU setting for patients presenting with minor stroke symptoms (NIHSS<10)
Major inclusion criteria:

  • Patients receiving IV tPA for presumed stroke within 4.5 hours of symptom onset
  • NIHSS <10 at presentation and at the end of tPA infusion
  • Age 18-80 years
  • Patients do not have ICU needs by the end of the tPA infusion

Major exclusion criteria:

  • Age <17 or >80
  • ICU need or indication by the end of the tPA infusion
  • NIHSS >9 at presentation or at the end of the tPA infusion

At the end of the one-hour tPA infusion, eligible patients will be consented for this study and will continue with neurocheck and vital signs Q 15 minutes x 4 in the ED. The patient may transfer to the BRU after the third Q 15 minute interval, so that they receive the 4th in the BRU. After arrival to the BRU, they will receive a set of vital signs and neurochecks upon arrival and at one hour, then Q 2 hours for 8 hours and then Q 4 hours until completing the 24 hour post tPA.

SMARTS: Study of Motor Learning and Acute Recovery Time Course in Stroke

Principle Investigator: John Krakauer, M.D.
Summary: This pilot study is to evaluate and quantify the biologic factors that are associated with the natural history of recovery over stroke, and to investigate the relationship between motor learning capacity and functional recovery over the course of 12 months post stroke. Funded by the James S. McDonnell Foundation.
Major inclusion criteria:

  • First ever clinical ischemic stroke which qualifies per MRI evaluation
  • Residual upper extremity weakness
  • Ability to provide informed consent

Major exclusion criteria:

  • Too mild upper extremity impairment
  • Age <21
  • Receptive aphasia, global inattention
  • Inability to give informed consent
  • Other co-morbid conditions, or illnesses

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Maryland Patients

To request an appointment or refer a patient, please call:
Neurology: 410-955-2228
Neurosurgery: 410-614-1533

Request an Appointment

Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259
Adult Neurosurgery: 410-955-6406
Pediatric Neurosurgery: 410-955-7337


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