Faculty investigative interests, in terms of both topics and methodologies, span virtually the entire spectrum of contemporary endocrine investigation. Each faculty preceptor has demonstrated the ability to involve trainees in their research, and successfully inculcate them with the principles and current techniques of endocrine and metabolic research. While several of the faculty have primary appointments in units other than Endocrine, the research focus of each faculty member is indeed in an endocrine or endocrine-related discipline. In this regard, our training program reflects our philosophy that the optimal training environment in which to learn to be a molecular endocrinologist is one that is scientifically rigorous; whether the preceptor considers him or herself an “endocrinologist” is less important than how the trainee views his or her own career development.
Faculty interact in several ways, including participation in formal and informal research conferences, teaching in courses, and informal scientific consultation. In several instances, faculty have collaborated with each other on projects of mutual interest and to provide an enriched learning environment for postdoctoral fellows. The faculty are highly interactive, as evidenced by frequent co-authorship of scientific manuscripts and joint supervision of doctoral and postdoctoral trainees.
The research interests (vida infra) of the training faculty reflect the disease-oriented approach to understanding pathophysiology and physiology that inculcates the “bench-to-bedside” philosophy of the training program.
Janet Crane, M.D. is director of the Pediatric Bone Health Clinic and a faculty member of the Center for Musculoskeletal Research. Her basic science/translational research efforts are devoted to understanding the cause of osteoporosis/skeletal fragility in childhood and identifying treatment targets. Dr. Crane's lab focuses on how manipulations of the bone marrow microenvironment promote bone formation.
Sheela Magge, M.D., M.S.C.E., is the director of the Division of Pediatric Endocrinology and Diabetes, and a clinician investigator dedicated to improving the lives of children with type 2 diabetes, obesity and insulin resistance, as well as the cardiovascular implications of these conditions. She is interested in the effects of differential body composition on cardiometabolic risk, and served as a multiple principal investigator for a study examining these effects in adolescents with Down Syndrome. She is also principal investigator on a new study of adolescents of South Asian ancestry and how racial differences in body composition affect cardiometabolic risk.
Risa Wolf, M.D.’s research focus is on diabetes. She is the principal investigator of a study implementing point-of-care diabetes retinopathy screening into pediatric diabetes care, a co-investigator for Trialnet, and the principal investigator for the Pediatric Diabetes Consortium site at Johns Hopkins. She also studies a novel family of proteins, called CTRPs, to determine their impact on glucose and lipid metabolism in the context of obesity and diabetes.
Sheng Wu, Ph.D., M.Sc., is investigating the actions of hyperandrogenemia through the androgen receptor on the development and regulation of metabolic and reproductive dysfunction. Multiple animal models (obesity, androgen implantation and conditional knockout), including a nonobese hyperandrogenemic mouse, are used to investigate the pathophysiology of polycystic ovary syndrome (PCOS), and the developmental factors and their target tissues that contribute to PCOS manifestation.
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