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Summary of Trial: 
The study is designed to contrast the relative efficacy of Carotid Artery Stenting (CAS) versus Carotid Endarterectomy (CEA) in preventing stroke, myocardial infarction, and death during a 30-day peri-procedural period, and stroke ipsilateral to the study artery over the 12 months follow-up period in patients with symptomatic and asymptomatic extracranial carotid stenosis.
Principal Investigator:Mahmoud B Malas, M.D., MHS, FACS
Study Coordinator:

Umair Qazi, M.D., MPH

Study Long Title: 

Carotid Revascularization Endarterectomy vs. Stenting Trial

Study Short Title: CREST
JHU IRB Number:


Funding Source:National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health (NIH)
Clinical Trial Site: The study enrolled a total of about 2500 randomized patients in multiple sites across the U.S.
Enrollment is now closed. Patients are in follow-up. Important results are being published in several respected clinical journals.

Johns Hopkins Bayview Medical Center
4940 Eastern Ave
Baltimore MD 21224
Start Date:2006
Anticipated End Date:2016
Compensation for Participating: None