The Intersection of Thrombosis and Immunity keyboard_arrow_right

Wednesday, June 09, 2021, 12 pm - 1 pm
Join guest speaker, Jane Freedman, M.D., as we explore her research in the intersection of thrombosis and immunity.

Jane Freedman, M.D., is the Edward Budnitz Professor of Cardiovascular Medicine at University of Massachusetts Medical School. She attends the Division of Cardiology and is the Director of Cardiovascular Research for the University of Massachusetts Memorial Heart and Vascular Center. Dr. Freedman is the editor-in-chief of the journal Circulation Research. Dr. Freedman completed her residency and cardiology fellowship at the Massachusetts General Hospital and at Brigham and Women’s Hospital, respectively. Dr. Freedman was granted full tenure at Georgetown University. She has also received young investigator awards from both the American Heart Association (AHA) and the American College of Cardiology (ACC). She was elected to the American Society for Clinical Investigation (ASCI) and the AUC program at the American College of Cardiology. Dr. Freedman served as an Interim Director at the Whitaker Cardiovascular Institute from 2007 to 2008 and was the Director of the NHLBI-sponsored Cardiovascular Research Training Grant at Boston University School of Medicine. She is an Associate Editor for Circulation Research and is on the editorial board and guest editor for several journals including: Circulation Research and Arteriosclerosis, Thrombosis and Vascular Biology. The major research initiatives in Dr. Freedman’s laboratory emphasize the regulation of pathways contributing to atherothrombotic disease and how these factors contribute to acute coronary syndromes.

Lessons learned from studying pathogenic variants in cardiac thin filament proteins keyboard_arrow_right

Wednesday, May 5th 2021, 1pm - 2pm
Dr. Jose Pinto is an Associate Professor at Florida State University College of Medicine. The Pinto lab investigates the molecular mechanisms underlying striated muscle thin filament regulation. The Pinto lab is devoted to understanding how pathogenic variants in sarcomeric proteins lead to cardiomyopathies and skeletal muscle disorders. The Pinto lab applies cryo-EM techniques to study thin and thick filament structure-function during physiological and pathological conditions.

Dr. Pinto’s lab has published on post-translational modifications (S-nitrosylation and phosphorylation) and mutations regulating calcium sensitivity and protein structure/interactions which modulate the function of the sarcomere. Already garnering nearly 2,000 citations, his works spans various myopathies including HCM, DCM, and RCM.

Imaging inflammation using CT: Is it time for clinical use? keyboard_arrow_right

Wednesday, June 16, 2021, 1 pm - 2 pm
Join guest speaker, Dr. Charalambos Antoniades as we explore his research in imaging inflammation using CT.

Charis Antoniades, M.D., Ph.D., F.R.C.P., F.E.S.C., is a Professor of Cardiovascular Medicine and Consultant Cardiologist. He was awarded his PhD title with honors on the genetics of premature myocardial infarction, and during his PhD studies he won multiple Young Investigator award competitions, including those of the European Society of Cardiology (ESC) twice, the ISHR and others. He is the Director of Acute Vascular Imaging Centre of the University of Oxford, the Deputy Head of the Division of Cardiovascular Medicine and director of the Oxford Academic cardiovascular CT programme (and Oxford Academic Cardiovascular CT Core Lab). He is also the Chair-Elect of the British Atherosclerosis Society. His research is focused on the study of the cross-talk between adipose tissue and the cardiovascular system, with specific interest in the non-invasive imaging of inflammation. He directs the Oxford Heart Vessels and Fat programme, and coordinates large national flagship programmes (such as the UK C19-CRC) and international multicentre studies (e.g. ORFAN study). His research has led to the development of novel imaging biomarkers using Computed Tomography, with major role in cardiovascular risk prognosis. He is also deputy editor of Cardiovascular Research, one of the editors of British Journal of Pharmacology and associate editor of Hellenic Journal of Cardiology.