Small Animal Cardiovascular Phenotyping and Model Core

heart function and geometry by ultrasound and doppler imaging

The Core Lab provides small animal cardiovascular phenotyping and model core for cardiovascular research.

Heart Function and Geometry by Ultrasound and Doppler Imaging

In This Section:

Heart Disease Models

We provide a variety of surgically generated heart disease models for use in mice or rats. This includes aortic or pulmonary artery banding for pressure-overload, myocardial infarction or ischemic reperfusion models of the left ventricle, and osmotic pump implantation for delivery of pharmaceuticals.
Our services include:

Chronic Electrocardiographic Telemetry

Electrocardiographic recordings from implantable transmitters are available via this service. Data Scientific systems are used, and data for multiple days (depending on need) based on telemetry provided.

Pressure Volume Loops

Analysis of Right or Left Heart Function

A miniature pressure-volume catheter is inserted into the relevant ventricle to measure in situ cardiac function using pressure-volume relationships. This is used to assess ventricular pressures, systolic and diastolic function, relaxation rates, filling rates, load-independent contractility parameters, diastolic compliance, and other indexes. These studies are not designed to be survival surgeries.
Our services include:

EchoDoppler Studies

Functional assessment of the heart and major blood vessels is provided by this service. Images are generated using one of two systems – a Accuson Sequoia echo-Doppler system or a state-of-the-art Visual-Sonics Vevo 2100 imaging system. The first is useful for routine M-mode and 2-D imaging, and for flow Doppler assessments.
The latter provides higher resolution imaging and also has tissue Doppler capabilities including speckle tracking for regional strain analysis. It would be the preferred imaging method for hearts with regional wall motion abnormalities, and when more subtle changes in function are anticipated. Functional imaging is also available to assess aortic diameter and wall thickening, flow in the aorta to assess vascular stiffening (pulse wave velocity, velocity time integral used to determine cardiac output, etc.).
Our services include:

Price List

Contact us for the Small Animal Cardiovascular Phenotyping and Model Core price list.


Nadan Wang
[email protected]

Michelle "Missy" Leppo
[email protected]

Shi Pan
[email protected]

David Kass
[email protected]