Cleidocranial Dysplasia (CCD)
Cleidocranial dysplasia is a rare genetic condition that affects teeth and bones, such as the skull, face, spine, collarbones and legs. The bones in people with CCD might be formed differently or might be more fragile than normal, and certain bones such as collarbones may be absent.
The name “cleidocranial dysplasia” comes from “cleido,” which refers to the collarbones, and “cranial,” which refers to the skull. Skull and collarbone abnormalities, along with dental abnormalities, are the main features of CCD.
What You Need to Know
- Cleidocranial dysplasia is a condition that is present at birth. It can be passed from a parent to a child, or it can appear at random.
- About one in 1 million people have cleidocranial dysplasia.
- Males and females are affected equally.
- CCD has no impact on cognitive function or intellect.
- Though some people with cleidocranial dysplasia require multiple surgeries, they can live long, full lives.
Signs of Cleidocranial Dysplasia
Many different bones in the body can be affected by CCD signs and symptoms, and in mild cases, these might be less obvious and harder to diagnose.
Skull and Face
- Nonclosing or delayed closure of the fontanelles, the soft spots between the skull plates in infants (normally, the skull plates knit together as the baby matures into childhood)
- A wide, flat or protruding forehead, sometimes with a vertical groove down the center
- A low, wide nasal bridge
- Wide-set eyes
- Small midface and lower jaw
- High-arched hard palate or cleft palate
- Small or absent sinuses, resulting in sinusitis
- Ear problems, including ear infections and sometimes hearing loss
- Baby teeth that do not come out on their own
- Impacted adult teeth that may be encased in bone and cannot grow in on their own.
- Supernumerary (extra) teeth
- Crowded teeth
- Malocclusion (teeth do not meet properly when biting), under bite or open bite
- Thin tooth enamel, which can make teeth more prone to caries (cavities)
- Short stature
- Incompletely formed or missing clavicles (collarbones), sloping shoulders
- Short fingers
- Narrow chest
- Extra or missing ribs
- Deformities in the pelvic bones, which can complicate childbirth
- Scoliosis (curvature of the spine)
- Genu valgum (knock knees)
- Osteopenia (decreased bone density)
- Sleep apnea
What causes cleidocranial dysplasia?
Cleidocranial dysplasia develops when there is a problem with the RUNX2 gene — which plays a role in the formation of osteoblasts, the cells that create bone in the developing body — and in the maturation of chondrocytes, the cells that produce cartilage.
Cleidocranial Dysplasia Diagnosis
CCD is diagnosed when the condition’s main features are found during a clinical examination and on X-rays. Genetic testing for a mutation in the RUNX2 gene can also help diagnose CCD.
Cleidocranial Dysplasia Treatment
Treatment depends on how the syndrome affects the patient. People with CCD may undergo multiple orthopaedic, facial reconstructive and dental procedures to improve their comfort, function and well-being. Recommended treatments might include:
- For children, facial reconstructive surgery on the bones of the face to reshape the forehead or cheekbones
- Spinal fusion procedures to support the spinal column
- Lower leg surgery to correct knock knees (knees that bend inward toward the center of the body)
- Surgical repair of fractures due to fragile bones
- Removal of small collarbone pieces that can affect the brachial plexus and cause arm pain or nerve problems
- Ear tubes to treat ear infections
- A protective helmet while playing sports to protect the open areas of the skull
- Calcium and vitamin D supplements to strengthen bones
Treatment of Dental Problems Caused by Cleidocranial Dysplasia
Orthodontics and oral surgery can address extra or impacted teeth. The first step is a careful assessment of each tooth, followed by extraction of any extra teeth. To maintain viable teeth, practitioners might remove gum tissue and guide growth of those teeth into the mouth with braces. For a faster result, some patients prefer implants, bridges or dentures. Sometimes jaw surgery is necessary to correct the bite.