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Our Approach to Brain Tumor Treatment Dr. Weingart standing in front of an MRI scanner machine

The Johns Hopkins Difference

By partnering with the Comprehensive Brain Tumor Center, you'll have access to the most advanced treatment options delivered by the field's leading experts who perform hundreds of brain tumor surgeries every year.


25+ specialists across a range of fields convenes weekly to discuss cases, formulate an optimal treatment plan and coordinate care with numerous specialties across Johns Hopkins Medicine.

Discovery and Innovation

Our experts don't just treat brain tumors, they study them in the lab, too, gaining deeper insight into how the disease works and which clinical trials might benefit specific patients. 


Our specialists consider many factors that guide their care recommendations, including your medical history, tumor location, type, grade, aggressiveness, tumor genetics and more.

Brain Tumor Treatment Advances

Johns Hopkins brain tumor researchers and clinicians are skilled in the most cutting-edge therapies, technologies and surgical techniques that help up improve patients' treatment outcomes and minimize side effects.
  • Intraoperative MRI

    Using MRI during surgery helps brain surgeons detect and address any challenges before the patient leaves the operating room.

  • Brachytherapy

    After removing the brain tumor, surgeons place radiotherapy “seeds” directly in the space left behind to prevent the tumor from growing back.

  • MRI-Guided Laser Ablation

    Guided by imaging techniques, surgeons remove the tumor with a laser for more accuracy and optimal preservation of healthy brain tissue.

  • Tumor-Treating Fields

    Brain tumors grow when their cells multiply in number. Electrical fields painlessly interrupt this process, slowing down the growth of tumors that cannot be removed by surgery alone.

  • Endoscopic and Minimally Invasive Surgery

    Devices like tubular retraction systems and certain surgical techniques allow doctors to spare healthy tissue while removing the tumor. These techniques include "eyebrow" (supra-orbital) craniotomy, "keyhole" (retro-signoid) craniotomy, translabyrinthine craniotomy and endonasal endoscopy.

  • Awake Craniotomies

    Brain tumor surgeons can navigate delicate structures of the brain, in some cases while the patient is awake, comfortable and providing feedback to the surgical team to help preserve vital brain function.

  • Intraoperative Chemotherapy

    Neurosurgeons can use small, biodegradable discs containing chemotherapy drugs to treat any remaining tumor cells during tumor removal.

  • Targeted Drug Therapies

    Based on a comprehensive genomic profile of your tumor, doctors will select the medications most likely to be effective in homing in on tumor cells and sparing healthy tissues.

Collaborative Care for Better Outcomes

  • Neuroplastic Surgery

    When a neurosurgeon works alongside a plastic surgeon, you get the best of both worlds: effective treatment for your condition and simultaneous reconstruction of any resulting skull defects.

  • Sidney Kimmel Cancer Center

    Kimmel Cancer Center offers vast resources for those diagnosed with brain cancer, including chemotherapy, radiation therapy, radiosurgery, clinical trials and more. Our close collaboration ensures smooth coordination of care for patients who can benefit from these treatments.

  • Proton Therapy

    Many children and adults with certain types of brain cancer can benefit from proton radiation therapy known for its ability to zero-in on the tumor with minimal effects to the surrounding tissue.

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