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Ischemic cardiovascular disease—conditions of reduced bloodflow to the heart—is the most common cause of death in the developed world. Countless lives could be saved if it were possible to coax new blood vessels to grow to treat such conditions. Researchers in our Vascular Biology program at ICE focus on angiogenesis and vascular biology with the ultimate goal of developing new clinical treatments. One specific focus is the use of bone marrow-derived vascular progenitor cells for the treatment of ischemic cardiovascular disease.
The Vascular Biology Program at Johns Hopkins' Institute for Cell Engineering
Researcher Gregg Semenza introduces the Vascular Biology Program, where scientists trace cells as they move through the body and study the relationship between low-oxygen conditions, blood vessel growth, and cancer.
- Jeff W.M. Bulte, Ph.D.
- Patrick Cahan, M.S., Ph.D.
- Assaf A. Gilad, Ph.D.
- Miroslaw Janowski, M.D., Ph.D.
- Gregg Semenza, M.D., Ph.D., Director
- Piotr Walczak, M.D., Ph.D.
Researchers Pinpoint Roadblocks to Lab-Grown Stem Cells’ Maturation
Johns Hopkins researchers report that a new study of mouse cells has revealed reasons why attempts to grow stem cells to maturity in the laboratory often fail, and provided a possible way to overcome such “developmental arrest.”
MRI Based On A Sugar Molecule Can Tell Cancerous From Noncancerous Cells
Imaging tests can detect tumors, but figuring out whether a growth is or isn’t cancer usually requires a biopsy. Now results of a Johns Hopkins study suggest that MRI could one day make biopsies more effective or even replace them altogether by noninvasively detecting telltale sugar molecules shed by the outer membranes of cancerous cells.
Toughest Breast Cancer May Have Met Its Match
Researchers at The Johns Hopkins University have discovered a way that breast cancer cells are able to resist the effects of chemotherapy — and they have found a way to reverse that process.
'Unsung' Cells Double the Benefits of a New Osteoporosis Drug
Experiments in mice with a bone disorder similar to that in women after menopause show that a scientifically overlooked group of cells are likely crucial to the process of bone loss caused by the disorder, according to Johns Hopkins researchers.
Cell's Recycling Center Implicated in Division Decisions
Researchers at The Johns Hopkins University have now identified a mechanism that overrides the cells’ warning signals, enabling cancers to continue to divide even without a robust blood supply.