Ischemic cardiovascular disease—conditions of reduced bloodflow to the heart—is the most common cause of death in the developed world. Countless lives could be saved if it were possible to coax new blood vessels to grow to treat such conditions. Researchers in our Vascular Biology program at ICE focus on angiogenesis and vascular biology with the ultimate goal of developing new clinical treatments. One specific focus is the use of bone marrow-derived vascular progenitor cells for the treatment of ischemic cardiovascular disease.
Stem Cells May Do Best With A Little Help From Their Friends
Like volunteers handing out cups of energy drinks to marathon runners, specially engineered “helper cells” transplanted along with stem cells can dole out growth factors to increase the stem cells’ endurance, at least briefly.
Researchers Step Closer to Custom-Building New Blood Vessels
Researchers at Johns Hopkins have coaxed stem cells into forming networks of new blood vessels in the laboratory, then successfully transplanted them into mice.
Making Cancer Less Cancerous
Researchers at Johns Hopkins have identified a gene that, when repressed in tumor cells, puts a halt to cell growth and a range of processes needed for tumors to enlarge and spread to distant sites.
Flipping the 'off' switch on cell growth
A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report.