Ischemic cardiovascular disease—conditions of reduced bloodflow to the heart—is the most common cause of death in the developed world. Countless lives could be saved if it were possible to coax new blood vessels to grow to treat such conditions. Researchers in our Vascular Biology program at ICE focus on angiogenesis and vascular biology with the ultimate goal of developing new clinical treatments. One specific focus is the use of bone marrow-derived vascular progenitor cells for the treatment of ischemic cardiovascular disease.
The Vascular Biology Program at Johns Hopkins' Institute for Cell Engineering
Researcher Gregg Semenza introduces the Vascular Biology Program, where scientists trace cells as they move through the body and study the relationship between low-oxygen conditions, blood vessel growth, and cancer.
Cell's Recycling Center Implicated in Division Decisions
Researchers at The Johns Hopkins University have now identified a mechanism that overrides the cells’ warning signals, enabling cancers to continue to divide even without a robust blood supply.
Signals Found That Recruit Host Animals’ Cells, Enabling Breast Cancer Metastasis
Working with mice, Johns Hopkins researchers report they have identified chemical signals that certain breast cancers use to recruit two types of normal cells needed for the cancers’ spread.
Rock And Rho: Proteins That Help Cancer Cells Groove
Biologists have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive.
Stem Cells May Do Best With A Little Help From Their Friends
Like volunteers handing out cups of energy drinks to marathon runners, specially engineered “helper cells” transplanted along with stem cells can dole out growth factors to increase the stem cells’ endurance, at least briefly.
Researchers Step Closer to Custom-Building New Blood Vessels
Researchers at Johns Hopkins have coaxed stem cells into forming networks of new blood vessels in the laboratory, then successfully transplanted them into mice.