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The Vascular Biology Program

Ischemic cardiovascular disease—conditions of reduced bloodflow to the heart—is the most common cause of death in the developed world. Countless lives could be saved if it were possible to coax new blood vessels to grow to treat such conditions. Researchers in our Vascular Biology program at ICE focus on angiogenesis and vascular biology with the ultimate goal of developing new clinical treatments. One specific focus is the use of bone marrow-derived vascular progenitor cells for the treatment of ischemic cardiovascular disease.


Jeff W.M. Bulte, Ph.D.
Assaf A. Gilad, Ph.D.
Miroslaw Janowski, M.D., Ph.D.
Gregg Semenza, M.D., Ph.D., Director
Piotr Walczak, M.D., Ph.D.

Latest News

hypoxia in breast cancer cells

Rock And Rho: Proteins That Help Cancer Cells Groove
Biologists have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive.


Injected stem cells

Stem Cells May Do Best With A Little Help From Their Friends
Like volunteers handing out cups of energy drinks to marathon runners, specially engineered “helper cells” transplanted along with stem cells can dole out growth factors to increase the stem cells’ endurance, at least briefly.


blood vessels

Researchers Step Closer to Custom-Building New Blood Vessels
Researchers at Johns Hopkins have coaxed stem cells into forming networks of new blood vessels in the laboratory, then successfully transplanted them into mice.


Resar cancer

Making Cancer Less Cancerous
Researchers at Johns Hopkins have identified a gene that, when repressed in tumor cells, puts a halt to cell growth and a range of processes needed for tumors to enlarge and spread to distant sites.



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