The future of regenerative medicine depends on fully understanding the regenerative properties of stem cells. Researchers in our Stem Cell Biology program at ICE work to understand the natural life cycle of human embryonic stem cells by carefully identifying and studying the molecules required for stem cells to self-renew and to differentiate into many cell types. In addition to improving methods for coaxing stem cells into desired cell types for both further study and potential therapies, the Stem Cell Biology team is heavily focused on developing induced pluripotent stem cells from adult tissues to improve current technologies to bring cell therapies to clinical care.
Recent Advancements in the Stem Cell Biology Program
Hongjun Song and Guo-li Ming discuss some of their latest research on how antidepressants increase the number of brain cells.
Lab-Grown, Virus-Free Stem Cells Repair Retinal Tissue in Mice
Investigators at Johns Hopkins report they have developed human induced-pluripotent stem cells capable of repairing damaged retinal vascular tissue in mice
Permanent Changes In Brain Genes May Not Be So Permanent After All
Cells turn off genes they don’t need, by attaching a chemical methyl group to the DNA. Scientists believed methyl groups could only stick to a particular DNA sequence. But, they've found they stick to other sequences in stem cells and brain neurons.
Signal Found To Enhance Survival Of New Brain Cells
A specialized type of brain cell that tamps down stem cell activity ironically, perhaps, encourages the survival of the stem cells' progeny, Johns Hopkins researchers report.
Researchers Step Closer to Custom-Building New Blood Vessels
Researchers at Johns Hopkins have coaxed stem cells into forming networks of new blood vessels in the laboratory, then successfully transplanted them into mice.
Osteoarthritis Progression Halted in Mice
Scientists have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, they now have evidence that the bone underneath the cartilage is also a key player and exacerbates the damage.