The future of regenerative medicine depends on fully understanding the regenerative properties of stem cells. Researchers in our Stem Cell Biology program at ICE work to understand the natural life cycle of human embryonic stem cells by carefully identifying and studying the molecules required for stem cells to self-renew and to differentiate into many cell types. In addition to improving methods for coaxing stem cells into desired cell types for both further study and potential therapies, the Stem Cell Biology team is heavily focused on developing induced pluripotent stem cells from adult tissues to improve current technologies to bring cell therapies to clinical care.
Osteoarthritis Progression Halted in Mice
Scientists have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, they now have evidence that the bone underneath the cartilage is also a key player and exacerbates the damage.