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The future of regenerative medicine depends on fully understanding the regenerative properties of stem cells. Researchers in our Stem Cell Biology program at ICE work to understand the natural life cycle of human embryonic stem cells by carefully identifying and studying the molecules required for stem cells to self-renew and to differentiate into many cell types. In addition to improving methods for coaxing stem cells into desired cell types for both further study and potential therapies, the Stem Cell Biology team is heavily focused on developing induced pluripotent stem cells from adult tissues to improve current technologies to bring cell therapies to clinical care.
The Stem Cell Biology Program at Johns Hopkins’ Institute for Cell Engineering
Researcher Hongjun Song introduces the Stem Cell Biology Program, where scientists get an up-close look at diseases by making stem cells with patients' DNA and growing affected cell types in the lab. Others are working on ways to make blood for transfusions or seeing how mental illness relates to problems in early brain development.
Neurons Constantly Rewrite Their DNA
Johns Hopkins scientists have discovered that neurons are risk takers: They use minor “DNA surgeries” to toggle their activity levels all day, every day.
Johns Hopkins Researchers Engineer Custom Blood Cells
Researchers have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells.
‘Crispr’ Science: Newer Genome Editing Tool Shows Promise in Engineering Human Stem Cells
The “genome editing” technology CRISPR is used by researchers to trim, disrupt, replace or add to sequences of an organism’s DNA. Now, scientists at have shown that the system also alters human stem cells.
'Unsung' Cells Double the Benefits of a New Osteoporosis Drug
Experiments in mice with a bone disorder similar to that in women after menopause show that a scientifically overlooked group of cells are likely crucial to the process of bone loss caused by the disorder, according to Johns Hopkins researchers.
Lab-Grown, Virus-Free Stem Cells Repair Retinal Tissue in Mice
Investigators at Johns Hopkins report they have developed human induced-pluripotent stem cells capable of repairing damaged retinal vascular tissue in mice