Seth Blackshaw, Ph.D.
The Blackshaw lab studies the molecular basis of cell fate specification in vertebrate retina and hypothalamus. The retina develops from the hypothalamus and consists of seven major cell types; defects in proper differentiation of these cells can result in blindness. The hypothalamus is a central physiological regulatory center composed of many cell types that are critical for regulating behaviors including the sleep-wake cycle and appetite.
To identify genes that control cell specification in the retina and hypothalamus, the research team has comprehensively profiled gene expressions throughout neurogenesis using both microarray and SAGE analysis. Additionally, the team has used high-throughput in situ hybridization to characterize expression patterns of more than 1,800 differentially expressed transcripts in both tissues. Current projects focus on analyzing the functions of those genes identified in the screen and using new markers to further characterize cell fate specification and differentiation in these tissues.
Meet Dr. Blackshaw
Associate Professor of Neuroscience
View a list of publications on PubMed.