Jonathan Schneck, M.D., Ph.D.
The Schneck lab studies the biophysical, genetic and environmental control of the T cell receptor. The research team has developed an acellular aAPC, a lego-like system that can be used to study T cells responses at a variety of different levels. Currently aAPC are being used to study manipulation of in vivo CTL responses and hold potential as a therapeutic approaches to augment both adoptive and active immunotherapy.
The team also develops approaches to understanding genetic regulation of glycosylation, among the most complex post-translational modifications with an extremely high level of diversity that has made it refractory to high-throughput analyses. One approach developed is a lectin microarray for defining mammalian cell surface glycan signatures and analyzing diverse cell processes including cell development and differentiation, cell-cell communication, pathogen-host recognition, and cell surface biomarker identification. On-going studies further explore use of this new technology in the identification of novel biomarkers.
On creating an artificial conductor to direct the immune system symphony:
Professor of Pathology
View a list of publications on PubMed.