Hongjun Song, Ph.D.
The Song lab studies mechanisms underlying mammalian neurogenesis, especially the cellular and molecular mechanisms that adult neural stem cells and their development in the mature central nervous system. The lab uses an integrated approach to study rodent and human neural stem cells in cell culture and in animal models utilizing technologies in molecular biology, cell biology, biochemistry, epigenetics, virology, histology, in vivo multiphoton confocal imaging, electrophysiology, mouse genetics and animal behaviors.
Current projects include characterizing properties of adult neural stem cells and neurogenesis; investigating intrinsic and extrinsic mechanisms regulating fate choice of adult neural stem cells and development of newborn neurons in the adult brain; characterizing contributions of newborn neurons at multiple levels in the adult brain, including single-cell electrophysiology in acute slices, local neuronal circuitry integration in vivo using optogenetic and multi-electrode recordings, and contribution to specific animal behaviors; exploring epigenetic mechanisms regulating adult neural plasticity.
The Song lab also is interested in understanding how defects in adult neurogenesis and epigenetic mechanisms contribute to mental disorders.
Meet Dr. Song
On using stem cells in the brain to study mental disorders:
(Click here for video transcription)
View a list of publications on PubMed.