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Bert Vogelstein

Bert Vogelstein

Department Affiliation: Sidney Kimmel Comprehensive Cancer Center; Pathology
Degree: M.D., Johns Hopkins University
Rank: Clayton Professor of Oncology and Pathology
Telephone Number: 410-955-8878
Fax Number: 410-955-0548
E-mail address: bertvog@gmail.com
School of Medicine Address: Room 589, Cancer Research Bldg., 1650 Orleans Street, Baltimore, MD 21231
 
Molecular genetics of human colorectal cancer.
 

Our group has studied the genetics of human cancer for 30 years and has helped establish several principles governing the pathogenesis of human neoplasia:   (i) Human tumors represent the expansion of a single transformed cell.  (ii) The initiation of this process and the expansion of the transformed cell are due to mutations in specific oncogenes and tumor suppressor genes.  (iii) These mutations occur in a preferred order as the tumor progresses from benign to malignant stages.  (iv) Mutations in the same genes can occur either through inherited or somatic pathways.  (v) Naturally occurring mutations in these genes can provide critical clues to their biochemical and physiologic functions.  (vi) Heritable alterations affecting genetic stability can lead to an accelerated accumulation of somatic mutations and an associated predisposition to cancer.

Our current work is devoted to using the genetic alterations responsible for cancer to develop new diagnostic tests to identify cancers earlier and new therapies to treat patients with advanced disease.   Novel approaches are essential for reducing the morbidity and mortality from the most aggressive cancer types, such as those of the pancreas.

 

Representative Publications:

  • Vogelstein, B., Papadopoulos, N., Velculescu, V.E., Zhou, S., Diaz, L.A. Jr. and Kinzler, K.W. Cancer genome landscapes. Science 339:1546-1558, 2013. Pub Med Reference
  • Le, D.T., Uram, J.N., Wang, H., Bartlett, B.R., Kemberling, H., Eyring, A.D., Skora, A.D., Luber, B.S., Azad, N.S., Laheru, D., Biedrzycki, B., Donehower, R.C., Zaheer, A., Fisher, G.A., Crocenzi, T.S., Lee, J.J., Duffy, S.M., Goldberg, R.M., de la Chapelle, A., Koshiji, M., Bhaijee, F., Huebner, T., Hruban, R.H., Wood, L.D., Cuka, N., Pardoll, D.M., Papadopoulos, N., Kinzler, K.W., Zhou, S., Cornish, T.C., Taube, J.M., Anders, R.A., Eshleman, J.R., Vogelstein, B., Diaz, L.A. Jr. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med. 372: 2509-2520, 2015. Pub Med Reference
  • Skora, A.D., Douglass, J., Hwang, M.S., Tam, A.J., Blosser, R.L., Gabelli, S.B., Cao, J., Diaz, L.A. Jr., Papadopoulos, N., Kinzler, K.W., Vogelstein, B. and Zhou, S. Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes. Proceedings of the National Academy of Sciences, U.S.A. 112: 9967-9972, 2015. Pub Med Reference
  • Cohen, J.D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., Douville, C., Javed, A.A., Wong, F., Mattox, A., Hruban, R.H., Wolfgang, C.L., Goggins, M.G., Dal Molin, M., Wang, T.L., Roden. R., Klein, A.P., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Vogelstein, J.T., Browne, J.D., Schoen, R.E., Brand, R.E, Tie, J., Gibbs, P., Wong, H.L., Mansfield, A.S., Jen, J., Hanash, S.M., Falconi, M., Allen, P.J., Zhou, S., Bettegowda, C., Diaz, L., Tomasetti, C., Kinzler, K.W., Vogelstein, B., Lennon, A.M., and Papadopoulos, N.  Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 359(6378):926-930, 2018. Pub Med Reference
  • Lennon, A.M., Buchanan, A.H., Kinde, I., Warren, A., Honushefsky, A., Cohain, A.T., Ledbetter, D.H., Sanfilippo, F., Sheridan, K., Rosica, D., Adonizio, C.S., Hwang, H.J., Lahouel, K., Cohen, J.D., Douville, C., Patel, A.A., Hagmann, L.N., Rolston, D.D., Malani, N., Zhou, S., Bettegowda, C., Diehl, D.L., Urban, B., Still, C.D., Kann, L., Woods, J., Salvati, Z.M., Vadakara, J., Leeming, R., Bhattacharya, P., Walter, C., Parker, A., Lengauer, C., Klein, A., Tomasetti, C., Fishman, E.K., Hruban, R.H., Kinzler, K.W., Vogelstein, B. and Papadopoulos N.   Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.  Science  Jul 3;369(6499):eabb9601, 2020. Journal-in-Process. Pub Med Reference  

Other graduate programs in which Dr. Vogelstein participates:

Cellular and Molecular Medicine