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Stuart C. Ray

Dr. Ray 

Department Affiliation: Primary: Medicine; Secondary: Viral Oncology; Health Sciences Informatics
Degree: M.D., Vanderbilt University
Rank: Professor
E-mail address:
School of Medicine Address: Rangos Building, Suite 532, 855 N. Wolfe Street, Baltimore, MD  21205

Computational Immunovirology of Chronic Viral Hepatitis  

Chronic viral hepatitis (due to HBV and HCV) is a major cause of liver disease worldwide, and an increasing cause of death in persons living with HIV/AIDS.  Our laboratory studies are aimed at better defining the host-pathogen interactions in these infections, with particular focus on humoral and cellular immune responses, viral evasion, inflammation, fibrosis progression, and drug resistance.  We are engaged in synthetic biology approaches to rational vaccine development and understanding the limits on the extraordinary genetic variability of HCV.

Representative Publications:

  • Mehta, S.H., Cox, A., Hoover, D.R., Wang, X.-H., Mao, Q., Ray, S., Strathdee, S.A., Vlahov, D., Thomas, D.L. Protection against persistence of Hepatitis C. Lancet 359(9316): 1478-1483, 2002.  Pub Med Reference
  • Ruff, C.T., Ray, S.C., Kwon, P., Zinn, R., Pendleton, A., Hutton, N., Ashworth, R., Gange, S., Quinn, T.C., Siliciano, R.F., Persaud, D. Persistence of Wild Type Virus and Lack of Temporal Structure in the Latent Reservoir for HIV-1 in Pediatric Patients with Extensive Antiretroviral Exposure. J Virology 76(18): 9481-9492, 2002. Pub Med Reference

  • Li, K., Foy, E., Ferreon, J.C., Nakamura, M., Ferreon, A.C.M., Ikeda, M., Ray, S.C., Gale, M., Lemon, S.M. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci (USA) 102(8): 2992-2997, 2005. Pub Med Reference  

  • Cox, A.L., Mosbruger, T., Mao, Q., Liu, Z., Wang, X.H., Yang, H.C., Sidney, J., Sette, A., Pardoll, D., Thomas, D.L., Ray, S.C. Cellular immune selection with hepatitis C virus persistence in humans. J Exp Med 201(11):1741-1752, 2005. Pub Med Reference  

  • Ray, S.C., Fanning, L., Wang, X.H., Netski, D.M., Kenny-Walsh, E., Thomas, D.L. Divergent and convergent evolution after a common-source outbreak of hepatitis C virus. J Exp Med 201(11):1753-1759, 2005. Pub Med Reference  

  • Balagopal, A., Philp, F.H., Astemborski, J., Block, T.M., Mehta, A., Long, R., Kirk, G.D., Mehta, S.H., Cox, A.L., Thomas, D.L., Ray, S.C. Human Immunodeficiency Virus-related Microbial Translocation and Progression of Hepatitis C. Gastroenterology 135(1):226-233, 2008. Pub Med Reference  
  • Dowd, K.A., Netski, D.M., Wang, X.H., Cox, A.L., Ray, S.C. Selection Pressure from Neutralizing Antibodies Drives Sequence Evolution during Acute Infection with Hepatitis C Virus. Gastroenterology 136(7):2377-2386, 2009. Pub Med Reference  

  • Liu, L., Fisher, B.E., Dowd, K.A., Astemborski, J., Cox, A.L., Ray, S.C. Acceleration of HCV envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection. J Virology 84(10): 5067-5077, 2010.  Pub Med Reference    

  • Munshaw, S., Bailey, J.R., Liu, L., Osburn, W.O., Burke, K.P., Cox, A.L., Ray, S.C. Computational reconstruction of Bole1a, a representative synthetic hepatitis C virus subtype 1a genome. J Virol. 86(10): 5915-21, 2012. doi: 10.1128/JVI.05959-11. Epub 2012 Mar 21. Pub Med Reference
  • Ray, S.C., Bailey, J.R., Thomas, D.L. Chapter 27, Hepatitis C; p.795-824. In: Fields Virology (Knipe, D.M., Howley, P.M., editors) Philadelphia, PA: Lippincott Williams & Wilkins; 2013.

Other graduate programs in which Dr. Ray participates:

Graduate Immunology Program